Frontiers in Medicine, 2018 Background: Atelectasis frequently develops in critically ill patients and may result in impaired gas exchange among other complications. The long-term effects of bronchoscopy on gas exchange and the effects on respiratory mechanics are largely unknown ...
Kim M. G. Smeijsters +13 more
doaj +1 more source
Surface mechanomyography and electromyography provide non-invasive indices of inspiratory muscle force and activation in healthy subjects [PDF]
, 2018 The current gold standard assessment of human inspiratory muscle function involves using invasive measures of transdiaphragmatic pressure (Pdi) or crural diaphragm electromyography (oesEMGdi).
Jané Campos, Raimon +6 more
core +2 more sources
Some frequency domain considerations upon human respiratory mechanics [PDF]
, 2004 The aim of this paper is to present a brief analysis of recent results considering human respiratory mechanics. The final purpose of the investigation is to provide a fast method for identification of airway mechanics, in order to assist the medical ...
De Keyser, Robain +1 more
core +1 more source
Accuracy of delivered airway pressure and work of breathing estimation during proportional assist ventilation: a bench study [PDF]
, 2016 Additional file 2: Table S1. Measured and theoretical mean airway pressure during inspiration (imeas and iTh) with different triggers in different respiratory ...
Aissam Lyazidi +4 more
core +8 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Modeling ambient temperature and relative humidity sensitivity of respiratory droplets and their role in Covid-19 outbreaks [PDF]
, 2020 One of the many unresolved questions that revolves around the Covid-19 pandemic is whether local outbreaks can depend on ambient conditions like temperature and relative humidity.
Basu, Saptarshi +4 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Context: Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle. Objective: To investigate possible effects of nifedipine on respiratory mechanics in the rat.
Alessandro Rubini +3 more
doaj +1 more source
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]
, 2011 Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong +4 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source