Results 51 to 60 of about 112,452 (299)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung disease [PDF]

, 2007
Background: Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants. Objective: To test the hypothesis that proportional assist ventilation ( PAV) will allow to lower the ventilator ...
Andreas Schulze, Eduardo Bancalari, Esther Rieger-Fackeldey, Lebowitz HH, Musante G, Nelson Claure, Poon CS, Poon CS, Ruth Everett, Schaller P, Schulze A, Schulze A, Schulze A, Schulze A, Schulze A, Schulze A, Tilo Gerhardt, Younes M   +17 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Respiratory function and mechanics in pinnipeds and cetaceans [PDF]

, 2017
Author Posting. © Company of Biologists, 2017. This article is posted here by permission of Company of Biologists for personal use, not for redistribution.
Armstrong, Bagnoli, Berend, Blix, Blix, Bostrom, Butler, Bélanger, Cetti, Christiansen, Clausen, Costidis, Cotten, Cozzi, Craig, Crapo, Davenport, Dearolf, Denison, Denison, Dolphin, Dolphin, Duffield, Epple, Epple, Fahlman, Fahlman, Fahlman, Fahlman, Fahlman, Fahlman, Fahlman, Fahlman, Falke, Falke, Fisher, Fitz-Clarke, Folkow, Galetke, Goudappel, Gutierrez, Hansel, Harrison, Henk, Hodanbosi, Hooker, Hooker, Hui, Hyatt, Irving, Johansson, Jordanoglou, Kasting, Kerem, Klatsky, Knudson, Kooyman, Kooyman, Kooyman, Kooyman, Kooyman, Kooyman, Kooyman, Kooyman, Kooyman, Kooyman, Krogh, Lafortuna, Leith, Leith, Leith, Lindholm, Lindholm, Linér, Lundgren, Macklem, Mate, Matthews, McCormick, McDonald, Mead, Miedler, Miller, Miller, Miller, Miller, Moore, Moore, Mortola, Mortola, Mortola, Murdaugh, Namati, Ninomiya, Noren, Noren, Odend'hal, Olsen, Olson, Piscitelli, Piscitelli, Ponganis, Ponganis, Reed, Reed, Ridgway, Ridgway, Ridgway, Ridgway, Ridgway, Ridgway, Rodríguez de la Gala-Hernández, Schaefer, Scholander, Scholander, Schorr, Smodlaka, Snyder, Spencer, Spragg, Stahl, Stocks, Sumich, Sumich, Sumich, Tarasoff, van der Hoop, Venegas, Vogl, Wahrenbrock, Welsch, Wessels, West, Williams, Wislocki, Wislocki, Wislocki, Würsig, Würsig   +138 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis [PDF]

, 2020
Background: Respiratory muscle dysfunction is an important health problem with high morbidity and mortality and associated costs in patients with bronchiectasis (BC).
Casuso-Holgado, Maria Jesus, de-la-Casa-Almeida, Maria, Jimenez Cebrian, Ana Maria, Martín Valero, Rocio, Moral Muñoz, José Antonio, Rodríguez Huguet, Manuel   +5 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Accuracy of chest auscultation in detecting abnormal respiratory mechanics in the immediate postoperative period after cardiac surgery

Jornal Brasileiro de Pneumologia
Objective: To investigate the accuracy of chest auscultation in detecting abnormal respiratory mechanics. Methods: We evaluated 200 mechanically ventilated patients in the immediate postoperative period after cardiac surgery.
Glaciele Xavier, César Augusto Melo-Silva, Carlos Eduardo Ventura Gaio dos Santos, Veronica Moreira Amado   +3 more
doaj   +1 more source