Results 241 to 250 of about 826,835 (308)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Negative trial but positive lesson: reframing immunotherapy resistance from one-size-fits-all to precision strategies. [PDF]

BMJ Oncol
Jiang Y, Xu Y, Xia Y.
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Respiratory oscillometry: the new kid on the lung function block. [PDF]

BMJ Open Respir Res
Assayag D, Johannson KA.
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

Clinical and Epidemiological Characteristics of Ventilator-associated Pneumonia in Pediatric Intensive Care Units. [PDF]

Adv Biomed Res
Babai S, Parastegari M, Zibanejad N.
europepmc   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Shotgun metagenomic profiling of bacterial microbiomes, metagenome-assembled genomes and antimicrobial resistance in respiratory and blood samples from Gambian children with pneumonia

Khan D, Espinoza JL, Tientcheu P, Otchere ID, Mohammed NI, Worwui A, Nicol MP, Kwambana-Adams B, Antonio M, Dupont CL.   +9 more
europepmc   +1 more source

The relationship between obstructive sleep apnea and insulin resistance in patients with type 2 diabetes mellitus: a cross-sectional observational study. [PDF]

J Thorac Dis
Sun H, Wu X, Ma G, Liu J, Guo X, Zhao Z.
europepmc   +1 more source

Doxycycline for Macrolide-Resistant <i>Mycoplasma pneumoniae</i> Pneumonia in Children: Clinical Updates and Therapeutic Insights Post-COVID-19. [PDF]

Infect Drug Resist
Chen R, Xu Z.
europepmc   +1 more source