Results 231 to 240 of about 826,835 (308)

Prophylactic immune priming with heat-killed <i>Lacticaseibacillus rhamnosus</i> combined with therapeutic <i>Lactiplantibacillus plantarum</i> cell-free supernatant protects against <i>Pseudomonas aeruginosa</i> lung infection in mice. [PDF]

Front Immunol
Gong W, Arellano-Arriagada L, Albarracin L, Argañaraz Aybar JN, Baillo A, Cisterna-Vergara S, Nishiyama K, Valdéz JC, Gobbato N, Kitazawa H, Villena J.   +10 more
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Early detection of nosocomial pathogens in air and surfaces using an innovative genetic approach for surveillance in healthcare settings. [PDF]

Antimicrob Resist Infect Control
Martínez-Murcia A, Navarro A, Miró-Pina C, García-Sirera A, Pérez L, García-Román V, Navarro-Gracia JF.   +6 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Acute respiratory and ocular effects of electronic cigarettes: A pre-post experimental study in healthy users. [PDF]

Tob Prev Cessat
Romero MS, Garcia-Basterra I, Martin SS, Valera JCC, Mesa AM, Garcia JL, Cano-Gamonoso MB, Agüero IA, Velasco-Garrido JL, Cesar EC.   +9 more
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Impact of COVID-19 Pandemic on Antibiotic Resistance Patterns of Common Bacterial Pathogens to Antibiotics in Northern Ghana. [PDF]

J Clin Lab Anal
Osumanu HA, Deberu ON, Abdul-Karim A, Alhassan A, Addae EK, Afriyie SO, Azure S, Lawal SA, Agboyie DD, Koyiri VC, Yakubu H, Weyori EW, Osei KM, Nuertey BD, Acheampong G.   +14 more
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

The impact of the COVID-19 pandemic on the epidemiology, clinical manifestations and molecular characteristics of <i>Mycoplasma pneumoniae</i>. [PDF]

Front Immunol
Yan L, Fu H, Zhang H, Dong H, Chen J, Yu L, Zhang L.   +6 more
europepmc   +1 more source