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Pharmacological management of human respiratory syncytial virus infection
Expert Opinion on Pharmacotherapy, 2020Human respiratory syncytial virus (hRSV) is the primary viral cause of respiratory diseases, leading to bronchiolitis and pneumonia in vulnerable populations. The only current treatment against this virus is palliative, and no efficient and specific vaccine against this pathogen is available.The authors describe the disease symptoms caused by hRSV, the
Alexis Kalergis +2 more
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Respiratory syncytial virus interaction with human airway epithelium
Trends in Microbiology, 2013Although respiratory syncytial virus (RSV) is a major human respiratory pathogen, our knowledge of how it causes disease in humans is limited. Airway epithelial cells are the primary targets of RSV infection in vivo, so the generation and exploitation of RSV infection models based on morphologically and physiologically authentic well-differentiated ...
Michael Shields +2 more
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HUMAN RESPIRATORY SYNCYTIAL VIRUS
2023Human Respiratory Syncytial Virus (RSV) has a significant role in the development of newborns' and children's' respiratory tract illnesses. It causes serious lower respiratory tract infections in newborns and young children. RSV causes widespread outbreaks of illness each year during the winter season. in the winter months of November through March RSV
Anto P V +2 more
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Human Respiratory Syncytial Virus: An Introduction
2016Human respiratory syncytial virus (RSV) is understood to be a significant human pathogen in infants, young children, and the elderly and the immunocompromised. Over the last decade many important mechanisms contributing to RSV infection, replication, and disease pathogenesis have been revealed; however, there is still insufficient knowledge which has ...
Patricia A, Jorquera +2 more
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Immunity to human and bovine respiratory syncytial virus
Archives of Virology, 1990Human and bovine respiratory syncytial viruses resemble each other closely. During annual winter outbreaks, they cause similar respiratory tract disease in infants and calves. The disease is most severe in children and calves between 1 and 3 months old, when maternal antibodies against the virus are usually present.
T G, Kimman, F, Westenbrink
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Update on human respiratory syncytial virus
Clinical Microbiology Newsletter, 2001Abstract Since its initial discovery 50 years ago, RSV has continued to generate strong and sustained efforts in the scientific and health care communities to develop modalities for prevention and treatment. Further studies that define the molecular evolution of RSV and the mechanisms by which it evades the immune response should facilitate the ...
Nahed Ismail, Barbara Reisner
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Human respiratory syncytial virus and Th1 chemokines.
La Clinica terapeutica, 2015The importance of the Type-1 helper (Th1) chemokines in RSV (respiratory syncytial virus) infection has been shown by several studies, in animal models, and in humans. The production of Th1 chemokines within the lower respiratory tract has been shown in patients with RSV bronchiolitis, particularly chemokine (C-X-C motif) ligand (CXCL)10/interferon-γ ...
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Purification of human respiratory syncytial virus fusion glycoprotein
Protein Expression and Purification, 2012Human respiratory syncytial virus (RSV) fusion glycoprotein (F) elicits neutralizing antibodies to RSV and has therefore attracted much attention as a suitable candidate antigen in the development of gene-based vaccines against RSV infections. However, a major obstacle in vaccine development has been the problem of antigen purification. To address this
Yanpeng, Zheng +5 more
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