Results 41 to 50 of about 66,312 (212)

Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome

Global Medical Genetics, 2023
This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with ...
Darja Kanduc
doaj   +1 more source

A novel host factor for human respiratory syncytial virus [PDF]

Communicative & Integrative Biology, 2017
Human respiratory syncytial virus (RSV) is the leading viral cause of severe lower respiratory disease in young children worldwide. As part of a genome-wide siRNA screen, we recently discovered that actin-related protein 2 (ARP2) is a host factor in the RSV replication cycle.
Masfique Mehedi, Peter L. Collins, Ursula J. Buchholz   +2 more
openaire   +3 more sources

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Evaluation of Human Respiratory Syncytial Virus and Human Parainfluenza Virus Type 3 among Hospitalized Children in Northwest of Iran

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Acute respiratory tract infections (ARTIs) are the leading cause of illnesses in children. Human respiratory syncytial virus (HRSV) and human parainfluenza viruses (HPIVs) are among the most common etiologic agents associated with viral ...
Zahra Ramezannia, Javid Sadeghi, Shahram Abdoli Oskouie, Mohammad Ahangarzadeh Rezaee, Hossein Bannazadeh Baghi, Arezou Azadi, Mahin Ahangar Oskouee   +6 more
doaj   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Respiratory syncytial virus glycoproteins uptake occurs through clathrin-mediated endocytosis in a human epithelial cell line

Virology Journal, 2008
Cell-surface viral proteins most frequently enter the cell through clathrin or caveolae endocytosis. Respiratory syncytial virus antigen internalization by immune cells is via caveolin, however, uptake of paramyxovirus cell membrane proteins by non ...
Gómez-García Beatriz, Sánchez-Hernández Carla, Gutiérrez-Ortega Abel   +2 more
doaj   +1 more source

Mitoxantrone Shows In Vitro, but Not In Vivo Antiviral Activity against Human Respiratory Syncytial Virus

Biomedicines, 2021
Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization.
Patricia G. de la Sota, Elena Lorente, Laura Notario, Carmen Mir, Oscar Zaragoza, Daniel López   +5 more
doaj   +1 more source

Occurrence of human respiratory syncytial virus in summer in Japan [PDF]

Epidemiology and Infection, 2016
SUMMARY In temperate zones, human respiratory syncytial virus (HRSV) outbreaks typically occur in cold weather, i.e. in late autumn and winter. However, recent outbreaks in Japan have tended to start during summer and autumn. This study examined associations of meteorological conditions with the numbers of HRSV cases reported in ...
Y, Shobugawa, T, Takeuchi, A, Hibino, M R, Hassan, R, Yagami, H, Kondo, T, Odagiri, R, Saito   +7 more
openaire   +2 more sources

Spray‐Dried mRNA‐LNP Powder Enabling Multi‐Route Delivery With 3‐Year Refrigerated Stability

Advanced Science, EarlyView.
Spray‐dried mRNA‐LNP powder with trehalose matrix enables reconstitution for parenteral delivery or direct administration via pulmonary and sublingual routes, maintaining protein expression comparable to liquid controls. The thermostable powder preserves colloidal stability, mRNA integrity, and biological activity for over 3 years at 2°C–8°C, while ...
Ashish Sarode, Priyal Patel, Frank DeRosa, Shrirang Karve, Regis Gervier   +4 more
wiley   +1 more source

Virus isolation and genotype identification of human respiratory syncytial virus in Guizhou Province, China

Brazilian Journal of Infectious Diseases, 2019
To investigate the genetic variation and molecular epidemiology characteristics of Human Respiratory Syncytial Virus (HRSV) in Guizhou Province, nasopharyngeal aspirates were collected from patients with acute respiratory infection (ARI) in Guizhou ...
Ting Zhao, Zhixu Ye, Binlin Wang, Yuxia Cui, Yingjie Nie, Bin Yang, Kun Chen, Hua Zhang, Fangfang Hu, Fuxun Yu   +9 more
doaj   +1 more source