Results 41 to 50 of about 53,062 (221)

Genetic diversity of the attachment protein of subgroup B respiratory syncytial viruses [PDF]

Journal of Virology, 1991
Respiratory syncytial (RS) virus causes repeated infections throughout life. Between the two main antigenic subgroups of RS virus, there is antigenic variation in the attachment protein G. The antigenic differences between the subgroups appear to play a role in allowing repeated infections to occur.
W M, Sullender, M A, Mufson, L J, Anderson, G W, Wertz   +3 more
openaire   +2 more sources

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Prevalence of respiratory viruses in children with respiratory tract infections during the COVID-19 pandemic era: a systematic review and meta-analysis

BMC Pulmonary Medicine
Background and aims The evaluation of the spread of respiratory viruses in the context of the COVID-19 pandemic is required to understand how SARS-CoV-2 may have impacted the spectrum of respiratory viruses among children.
Pegah Khales, Mohammad Hossein Razizadeh, Saied Ghorbani, Afagh Moattari, Hassan Saadati, Ahmad Tavakoli   +5 more
doaj   +1 more source

The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus

Nature Communications
The role of viral interaction—where one virus enhances or inhibits infection with another virus—in respiratory virus transmission is not well characterized.
Jessica C. Ibiebele, Elie-Tino Godonou, Amy P. Callear, Matthew R. Smith, Rachel Truscon, Emileigh Johnson, Marisa C. Eisenberg, Adam S. Lauring, Arnold S. Monto, Sarah Cobey, Emily T. Martin   +10 more
doaj   +1 more source

Etiology and seasonality of viral respiratory infections in children under 5 years of age in Bucaramanga, Colombia

Iatreia, 2017
Objective: To describe viruses associated with respiratory infection in children in Bucaramanga, the main city in northeastern Colombia. Materials and methods: Descriptive study with prospective collection.
García-Corzo, Jorge Raúl, Niederbacher-Velásquez, Jurg, González-Rugeles, Clara, Rodríguez-Villamizar, Laura, Machuca-Pérez, Mayra, Torres-Prieto, Alexánder, Ortiz Rodríguez, Gloria, Romero-Salazar, Mónica   +7 more
doaj   +1 more source

Prevalence of respiratory viruses using polymerase chain reaction in children with wheezing, a systematic review and meta-analysis.

PLoS ONE, 2020
IntroductionWheezing is a major problem in children, and respiratory viruses are often believed to be the causative agent. While molecular detection tools enable identification of respiratory viruses in wheezing children, it remains unclear if and how ...
Cyprien Kengne-Nde, Sebastien Kenmoe, Abdou Fatawou Modiyinji, Richard Njouom   +3 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

MultNAT HPV16/18 Assay: A Simple, Rapid, and Low‐Cost Polymerase Chain Reaction Method for the Detection of HPV16 and HPV18 Suitable for Point‐of‐Care Testing

Cancer Nexus, EarlyView.
ABSTRACT Aim Persistent high‐risk HPV infection can lead to the development of precancerous lesions, potentially progressing to invasive cancer. HPV status serves not only as a prognostic marker for squamous cell carcinoma (HNSCC) like oropharyngeal squamous cell carcinomas (OPSCC) but also significantly influences clinical management and treatment ...
Min Wang, Yueping Li, Qingting Bu, Peng Xiong, Suhang Li, Xiaoyan Li, Sisi Chen, Yanqiong Zhou, Siyu Li, Xiaojuan Jia   +9 more
wiley   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Viral etiology in infants hospitalized for acute bronchiolitis

The Turkish Journal of Pediatrics, 2014
Acute bronchiolitis is predominantly a viral disease. Respiratory syncytial virus is the most common agent, but other newly identified viruses have also been considered as causes.
Dilek Azkur, Eda Özaydın, Emine Dibek-Mısırlıoğlu, Emine Vezir, Duygu Tombuloğlu, Gülşen Köse, Can N Kocabaş   +6 more
doaj