Results 71 to 80 of about 1,201,684 (350)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effects of mechanical insufflation-exsufflation on lung function and complications in cardiac surgery patients: a pilot study

Journal of Cardiothoracic Surgery, 2021
Background Postoperative positive pressure lung expansion is associated with decreased pulmonary complications and improved clinical outcomes. The aim of the present study was to compare the differences in post-operative pulmonary complications and ...
Meng-Fang Wu, Tsai-Yu Wang, Da-Shen Chen, Hsiu-Fong Hsiao, Han-Chuang Hu, Fu-Tsai Chung, Ting-Yu Lin, Shu-Min Lin   +7 more
doaj   +1 more source

Clinical and molecular features and therapeutic perspectives of spinal muscular atrophy with respiratory distress type 1 [PDF]

, 2015
Spinal muscular atrophy with respiratory distress (SMARD1) is an autosomal recessive neuromuscular disease caused by mutations in the IGHMBP2 gene, encoding the immunoglobulin μ-binding protein 2, leading to motor neuron degeneration.
Corti, Stefania, Parente, Valeria, Porro, Francesca, Rinchetti, Paola, Vanoli, Fiammetta   +4 more
core   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Changes in initial COPD treatment choice over time and factors influencing prescribing decisions in UK primary care : a real-world study [PDF]

, 2016
Acknowledgements Samantha Holmes (CircleScience, an Ashfield Company, part of UDG Healthcare plc) and Paul Hutchin (contracted to CircleScience, an Ashfield Company, part of UDG Healthcare plc) provided medical writing assistance.
Baldwin, Michael, Brusselle, Guy, Davis, Emily, Gruffydd-Jones, Kevin, Jones, Rupert, Keininger, Dorothy L., Miravitlles, Marc, Price, David, Rigazio, Anna, Stewart, Rebecca   +9 more
core   +3 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Awareness, uptake, and barriers to vaccination against respiratory tract infections in patients with diabetes mellitus: A multi-center study in Saudi Arabia

Human Vaccines & Immunotherapeutics
Diabetes mellitus (DM) predisposes individuals to respiratory tract infections (RTIs), making vaccination an essential preventive measure; however, evidence regarding vaccination awareness, uptake, and barriers among DM patients in Saudi Arabia is ...
Abdulelah M. Aldhahir, Mohammed M. Alyami, Ahmed H. Alasimi, Amirah M. Alqahtani, Roaa E. Mousa, Shahad A. Alqahtani, Lubna M. Alhalbub, Ozuf A. Mohammed, Saleh M. Alosaimi, Ali S. AlQahtani, Abdullah A. Alqarni, Jaber S. Alqahtani, Hussin Albargi, Maryam M. Almulhem, Rayan A. Siraj, Hassan Alwafi   +15 more
doaj   +1 more source

Respiration-Induced Intraorgan Deformation of the Liver: Implications for Treatment Planning in Patients Treated With Fiducial Tracking. [PDF]

, 2017
Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation
Anwar, Mekhail, Chang, Albert J, Descovich, Martina, Gottschalk, Alexander R, Paulsson, Anna K, Pinnaduwage, Dilini, Sudhyadhom, Atchar, Yom, Sue S   +7 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Mechanical ventilation management and airway pressure release ventilation practice in acute respiratory distress syndrome: A cross‐sectional survey of intensive care unit clinicians in mainland China

Hong Kong Journal of Emergency Medicine
Background Airway pressure release ventilation (APRV) has become increasingly popular for the management of acute respiratory distress syndrome (ARDS); however, its clinical impact remains a topic of debate.
Yinxia Lv, Xinyang Jin, Meiling Dong, Lan Yang, Bo Wang, Guopeng Liang, Peng Wang, Xiaorong Jing, Yiyi Yang, Yunqin Yang, Zhen Wang, Xuelian Liao, Wei Yang, Shuo Zhu, Mandie Lu, Yan Kang, Yongfang Zhou   +16 more
doaj   +1 more source