Results 61 to 70 of about 739,590 (261)

Do Primary Care Providers in Saudi Arabia Have Sufficient Knowledge to Support COPD Management and Patient Education? A National Cross-Sectional Survey

Journal of Multidisciplinary Healthcare
Rayan A Siraj,1 Ahmed M Al Rajeh,1 Maryam M Almulhem,1 Mushabbab A Alahmari,2,3 Abdulelah M Aldhahir,4 Abdullah A Alqarni,5,6 Jaber S Alqahtani,7 Saeed M Alghamdi,8 Nowaf Y Alobaidi,9,10 Abdullah Alruwaili,10,11 Saleh S Algarni,12,13 Abdulrhman S ...
Siraj RA, Al Rajeh AM, Almulhem MM, Alahmari MA, Aldhahir AM, Alqarni AA, Alqahtani JS, Alghamdi SM, Alobaidi NY, Alruwaili A, Algarni SS, Alghamdi AS, Alyami MM, Alrhaili MR, Alsolami NA   +14 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Bibliometric Analysis of Pulmonary Function Testing in Differentiating Asthma From COPD: Trends, Impact, and Emerging Research Areas

Journal of Multidisciplinary Healthcare
Noor Al Khathlan,1 Lama Omar Badghish,1 Hanin Hamed Alrehaili,2 Khalid Hamoud Olayan Al Luhaybi,2 Moayed Abdullah Alnakhli,3 Abdulhadi Jameel Alotaibi4 1Department of Respiratory Care, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal ...
Al Khathlan N, Badghish LO, Alrehaili HH, Al Luhaybi KHO, Alnakhli MA, Alotaibi AJ   +5 more
doaj  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Association of prior interstitial lung disease awareness with knowledge, attitudes, and practices in Saudi Arabia: a national cross-sectional study

Frontiers in Public Health
IntroductionInterstitial lung diseases (ILDs) are a heterogeneous group of diffuse parenchymal lung disorders, including idiopathic interstitial pneumonias, connective-tissue-disease–associated ILD and sarcoidosis.
Malik A. Althobiani, Malik A. Althobiani, Husam I. Alahmadi, Fatma Almaghlouth, Turky Zafir, Ali Alshamrani, Ziyad Alalawi, Mazen M. Homoud, Hanin Alghamdi, Heba M. Bintalib, Heba M. Bintalib, Mouaid Aljehani, Abdulalrahman Alharbi, Jaber S. Alqahtani, Abdullah Sakkat, Hajed M. Al-Otaibi, Abdullah A. Alqarni, Anne-Marie Russell   +17 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Impact of High-Flow Nasal Cannula for Chronic Obstructive Pulmonary Disease Exacerbation: A Systematic Review of Clinical and Physiological Outcomes

International Journal of COPD
Ziyad F Al Nufaiei,1,2 Jameel Zaid Hakeem1,21Respiratory Therapy Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 2King Abdullah International Medical Research Center, Jeddah ...
Al Nufaiei ZF, Hakeem JZ
doaj  

Impact of neurophysiological respiratory facilitation techniques on arterial blood gas parameters in pediatric patients with bronchial pneumonia

Bulletin of Faculty of Physical Therapy
Background Bronchial pneumonia remains a significant cause of morbidity, particularly in pediatric populations. This study aimed to evaluate the impact of neurophysiological respiratory facilitation techniques on arterial blood gas parameters in ...
Omnia Kotb, Akram Sayed, Ramy Draz, Asmaa El Mesiry   +3 more
doaj   +1 more source

A high content, phenotypic ‘scar-in-a-jar’ assay for rapid quantification of collagen fibrillogenesis using disease-derived pulmonary fibroblasts

BMC Biomedical Engineering, 2019
Background Excessive extracellular matrix (ECM) deposition is a hallmark feature in fibrosis and tissue remodelling diseases. Typically, mesenchymal cells will produce collagens under standard 2D cell culture conditions, however these do not assemble ...
Robert B. Good, Jessica D. Eley, Elaine Gower, Genevieve Butt, Andrew D. Blanchard, Andrew J. Fisher, Carmel B. Nanthakumar   +6 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source