Results 71 to 80 of about 7,342,729 (336)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Virtual pulmonary rehabilitation approaches in patients with post COVID syndrome: a pilot study

BMC Pulmonary Medicine
Background The characteristics of optimal virtual pulmonary rehabilitation (PR) for individuals with post-COVID syndrome (PCS) have not been identified.
Antonio Sarmento, Rachel Adodo, Greg Hodges, Sandra C. Webber, Diana C. Sanchez-Ramirez   +4 more
doaj   +1 more source

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up

Journal of the American College of Cardiology, 2020
Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, due to excessive ...
B. Bikdeli, Mahesh V. Madhavan, D. Jiménez, Taylor Chuich, Isaac Dreyfus, Elissa Driggin, C. Nigoghossian, W. Ageno, M. Madjid, Yutao Guo, Liang Tang, Yu Hu, Jay Giri, M. Cushman, I. Quéré, E. Dimakakos, C. M. Gibson, G. Lippi, E. Favaloro, J. Fareed, J. Caprini, A. Tafur, John R. Burton, D. Francese, Elizabeth Y. Wang, A. Falanga, C. McLintock, B. Hunt, A. Spyropoulos, G. Barnes, J. Eikelboom, I. Weinberg, S. Schulman, M. Carrier, G. Piazza, J. Beckman, P. Steg, G. Stone, S. Rosenkranz, S. Goldhaber, Sahil A. Parikh, M. Monreal, H. Krumholz, S. Konstantinides, J. Weitz, G. Lip   +45 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease

Medicina
Background and Objectives: Recent studies suggest that hydrogen gas possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to explore the therapeutic potential of hydrogen gas and assess its safety and tolerability in ...
Shih-Feng Liu, Chin-Ling Li, Hui-Ching Lee, Hui-Chuan Chang, Jui-Fang Liu, Ho-Chang Kuo   +5 more
doaj   +1 more source

The impact of aerosolized mucolytic agents on the airflow resistance of bacterial filters used in mechanical ventilation

Journal of the Formosan Medical Association, 2015
In order to reduce the contamination in the ventilator, bacterial filters were placed on the expiratory limb of a ventilator circuit. Aerosolized mucolytic agents may increase the resistance of the ventilator.
Han-Chung Hu, Hsin-Chun Liu, Yen-Huey Chen, Chung-Chi Huang, Gwo-Hwa Wan, Lan-Ti Chou, Meng-Jer Hsieh, Ning-Hung Chen, Cheng-Ta Yang, Kuo-Chin Kao   +9 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study

Pharmaceutics, 2020
We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation.
Tien-Pei Fang, Yu-Ju Chen, Tsung-Ming Yang, Szu-Hu Wang, Ming-Szu Hung, Shu-Hua Chiu, Hsin-Hsien Li, James B. Fink, Hui-Ling Lin   +8 more
doaj   +1 more source

Extrahepatic complications of liver transplantation. [PDF]

, 1985
The massive surgical assault associated with hepatic transplantation makes a high frequency of complications almost inevitable. In this review of 225 patient records, selected at random from cases of liver transplantation in Pittsburgh over a 2 1/2 year ...
Shaw, BW, Starzl, TE, Wood, RP
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source