Results 51 to 60 of about 20,074 (213)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

COPD severity in some provinces of the Department of Boyacá (Colombia) according to the ALAT 2019 and GOLD 2022 guidelines

Revista de la Facultad de Medicina
Introduction: Chronic obstructive pulmonary disease (COPD) is a condition that progressively limits the ability to perform exercise and activities of daily living, negatively impacting quality of life.
María del Pilar Rojas-Laverde, Sandra Patricia Corredor-Gamba, Alba Yanira Polania-Robayo, Marcela América Roa-Cubaque   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Awareness, uptake, and barriers to vaccination against respiratory tract infections in patients with diabetes mellitus: A multi-center study in Saudi Arabia

Human Vaccines & Immunotherapeutics
Diabetes mellitus (DM) predisposes individuals to respiratory tract infections (RTIs), making vaccination an essential preventive measure; however, evidence regarding vaccination awareness, uptake, and barriers among DM patients in Saudi Arabia is ...
Abdulelah M. Aldhahir, Mohammed M. Alyami, Ahmed H. Alasimi, Amirah M. Alqahtani, Roaa E. Mousa, Shahad A. Alqahtani, Lubna M. Alhalbub, Ozuf A. Mohammed, Saleh M. Alosaimi, Ali S. AlQahtani, Abdullah A. Alqarni, Jaber S. Alqahtani, Hussin Albargi, Maryam M. Almulhem, Rayan A. Siraj, Hassan Alwafi   +15 more
doaj   +1 more source

Aerosol therapy in relation to retinopathy of prematurity in mechanically ventilated preterm infants

BMC Pulmonary Medicine, 2019
Background Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have not yet been explored.
Mei-Chin Yang, Hsiu-Feng Hsiao, Hsiu-Li Tseng, Ya-Wen Chiu, Yi-Hao Weng   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mechanical ventilation management and airway pressure release ventilation practice in acute respiratory distress syndrome: A cross‐sectional survey of intensive care unit clinicians in mainland China

Hong Kong Journal of Emergency Medicine
Background Airway pressure release ventilation (APRV) has become increasingly popular for the management of acute respiratory distress syndrome (ARDS); however, its clinical impact remains a topic of debate.
Yinxia Lv, Xinyang Jin, Meiling Dong, Lan Yang, Bo Wang, Guopeng Liang, Peng Wang, Xiaorong Jing, Yiyi Yang, Yunqin Yang, Zhen Wang, Xuelian Liao, Wei Yang, Shuo Zhu, Mandie Lu, Yan Kang, Yongfang Zhou   +16 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Why Saudi Respiratory Therapists Struggle with Research: An Evidence-Based Analysis

Advances in Medical Education and Practice
Mohammed M Alqahtani,1– 3 Hassan Aljohani,1– 3 Saleh S Algarni,1– 3 Mobarak K Alqahtani,1– 3 Taha T Ismaeil,1– 3 Mutab F Alotaibi,1,3 Fahad H Al Enazi,4,5 Turki M Alanazi,4,5 Ziyad F Al Nufaiei6– 8 1Department of Respiratory Therapy, College of Applied ...
Alqahtani MM, Aljohani H, Algarni SS, Alqahtani MK, Ismaeil TT, Alotaibi MF, Al Enazi FH, Alanazi TM, Al Nufaiei ZF   +8 more
doaj