Results 31 to 40 of about 20,074 (213)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Insomnia symptoms and their association with academic performance among respiratory therapy students in Saudi Arabia and the United States

Scientific Reports
Despite the growing recognition of insomnia among students, research specifically targeting respiratory therapy (RT) students remains limited. Therefore, this study aimed to assess the prevalence of insomnia symptoms and their association with academic ...
Ahmed H. Alasimi, Kyle J. Brandenberger, Ralph D. Zimmerman, Shi H. Shan   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Drug Concentrations in the Air and their Influencing Factors in a Pediatric Intensive Care Unit

Aerosol and Air Quality Research
Aerosolized drug therapy is a common approach in treating respiratory diseases in clinical practice. This study aimed to assess air quality in the pediatric intensive care unit (PICU) of the medical center and investigate variations in drug concentration
Hui-Yun Tseng, Yi-Ting Tsai, Ying-Shiuan Su, Po-Pei Peng, Gwo-Hwa Wan   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Awareness and practice of airway pressure release ventilation mode in acute respiratory distress syndrome patients among nurses in Saudi Arabia

BMC Nursing
Background This study aimed to assess the knowledge and current practice of using the airway pressure release ventilation (APRV) mode with acute respiratory distress syndrome (ARDS) patients and identify barriers to not using this mode of ventilation ...
Abdulelah M. Aldhahir, Abdullah A. Alqarni, Mohammed A. Madkhali, Hussain H. Madkhali, Abdullah A. Bakri, Mohammad A. Shawany, Ahmed H. Alasimi, Abdullah S. Alsulayyim, Jaber S. Alqahtani, Mohammed M. Alyami, Saeed M. Alghamdi, Omar A. Alqarni, Ali Hakamy   +12 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Clinical practices, self-confidence, and perceived barriers in tracheostomy care among respiratory therapists in Saudi Arabia: a national cross-sectional study

BMC Medical Education
Background Tracheostomy care is a critical aspect of respiratory therapy, requiring specialized knowledge and adherence to standardized protocols to ensure optimal patient outcomes.
Abdulelah M. Aldhahir, Ahmed H. Alasimi, Yunus A. Jothmi, Muhannad N. Khowaji, Abdullah A. Najaei, Jehad M. Rayyani, Ammar N. Alwadani, Abdullah A. Alqarni, Jaber S. Alqahtani, Rayan A. Siraj, Munyra Alhotye, Mohammed A. Reyany, Mohamed H. Hakamy, Mohammad A. Shawany, Ali Hakamy   +14 more
doaj   +1 more source

Randomized Double-Blind Trial of the Effects of Humidified Compared with Nonhumidified Low Flow Oxygen Therapy on the Symptoms of Patients

Canadian Respiratory Journal, 1997
OBJECTIVE: To determine the effects of humidified versus nonhumidified low flow oxygen therapy on the subjective symptoms of patients.
Darcy Andres, Norma Thurston, Rollin Brant, Ward Flemons, Doreen Fofonoff, Ardis Ruttimann, Sandra Sveinson, Carol Neil   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source