Results 41 to 50 of about 739,590 (261)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

COPD severity in some provinces of the Department of Boyacá (Colombia) according to the ALAT 2019 and GOLD 2022 guidelines

Revista de la Facultad de Medicina
Introduction: Chronic obstructive pulmonary disease (COPD) is a condition that progressively limits the ability to perform exercise and activities of daily living, negatively impacting quality of life.
María del Pilar Rojas-Laverde, Sandra Patricia Corredor-Gamba, Alba Yanira Polania-Robayo, Marcela América Roa-Cubaque   +3 more
doaj   +1 more source

The impact of aerosolized mucolytic agents on the airflow resistance of bacterial filters used in mechanical ventilation

Journal of the Formosan Medical Association, 2015
In order to reduce the contamination in the ventilator, bacterial filters were placed on the expiratory limb of a ventilator circuit. Aerosolized mucolytic agents may increase the resistance of the ventilator.
Han-Chung Hu, Hsin-Chun Liu, Yen-Huey Chen, Chung-Chi Huang, Gwo-Hwa Wan, Lan-Ti Chou, Meng-Jer Hsieh, Ning-Hung Chen, Cheng-Ta Yang, Kuo-Chin Kao   +9 more
doaj   +1 more source

Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study

Pharmaceutics, 2020
We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation.
Tien-Pei Fang, Yu-Ju Chen, Tsung-Ming Yang, Szu-Hu Wang, Ming-Szu Hung, Shu-Hua Chiu, Hsin-Hsien Li, James B. Fink, Hui-Ling Lin   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Why Saudi Respiratory Therapists Struggle with Research: An Evidence-Based Analysis

Advances in Medical Education and Practice
Mohammed M Alqahtani,1– 3 Hassan Aljohani,1– 3 Saleh S Algarni,1– 3 Mobarak K Alqahtani,1– 3 Taha T Ismaeil,1– 3 Mutab F Alotaibi,1,3 Fahad H Al Enazi,4,5 Turki M Alanazi,4,5 Ziyad F Al Nufaiei6– 8 1Department of Respiratory Therapy, College of Applied ...
Alqahtani MM, Aljohani H, Algarni SS, Alqahtani MK, Ismaeil TT, Alotaibi MF, Al Enazi FH, Alanazi TM, Al Nufaiei ZF   +8 more
doaj  

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

The Associations of Anaemia Status and Body Mass Index with Asthma Severity in Saudi Arabia: A Comparative Study

Journal of Asthma and Allergy
Alaa A Bugis,1– 3 Bussma Bugis,4 Abdulsalam Alzahrani,1– 3 Ali Hasan Alamri,1– 3 Hamad Hani Almalki,1– 3 Jamal Hassan Alshehri,1– 3 Abdullah Ali Alqarni,1– 3 Faisal A Turkestani1– 3,5 1Respiratory Therapy Program, College of Applied Medical Sciences ...
Bugis AA, Bugis B, Alzahrani A, Alamri AH, Almalki HH, Alshehri JH, Alqarni AA, Turkestani FA   +7 more
doaj