PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Impact of the 10-valent pneumococcal conjugate vaccine on the incidence of respiratory and ENT diseases and antibiotic consumption in children under 5 years of age in Barnaul [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2018 Objective. To evaluate epidemiological efficacy of the 10-valent pneumococcal conjugated vaccine (PCV10) as assessed by the number of episodes of respiratory tract and ENT diseases and by the number of antibiotic courses prescribed for those diseases in
Kozyanova Yu.A., Safyanova T.V.
doaj
Follicular Bronchiolitis in a Nigerian Female Child: A Case Report and Review of the Literature
Case Reports in Pediatrics, 2016 Small airways diseases are not uncommon in childhood. They account for about 28.4% of hospital admissions for lower respiratory tract infections in South West Nigeria, most of which are due to respiratory syncytial virus (RSV) infection.
Nzechukwu Zimudo Ikeri +6 more
doaj +1 more source
Recommendation by the German Respiratory Tract League on Sports and Physicol Training in Patients with Obstructive Disease of the Respiratory Tract (COPD) [PDF]
, 2000 H Worth +10 more
openalex +1 more source
Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen
Advanced Science, EarlyView.Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang +12 more
wiley +1 more source
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
Advanced Science, EarlyView.During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
Respiratory tract diseases and cytokine.
Nihon Naika Gakkai Zasshi, 1995 サイトカインは,リンパ球,マクロファージなどの細胞から産生される免疫反応・炎症を調節・制御する因子である.多種類のサイトカインが発見され,呼吸器疾患においてもサイトカインがその病態に関与する事が明らかとなり,あるいは治療に応用されている.主要サイトカインとしては,インターロイキン(IL-1～IL-10),インターフェロン,コロニー刺激因子(CSF),腫瘍壊死因子(TNF)などが知られている.肺線維症においては線維芽細胞増殖に対し, PDGFとIGF-Iが重要な働きをしている事が知られている.サルコイドーシスにおいては, TNF-α, IL-6, PDGF, GM-CSFが肺局所で増加し,肉芽腫形成に関与していると推測されている.気管支喘息では, IL-5は好酸球を活性化し, IgE産生については ...
openaire +2 more sources
Design of E-nose as an Instrument Identification of Diseases Through the Respiratory Tract
, 2020 Muhammad Yakob +3 more
openalex +1 more source
Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source