Results 101 to 110 of about 910,981 (387)

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

The etiology of lower respiratory tract infections in people with diabetes.

Pneumonologia i Alergologia Polska, 2015
Patients with diabetes mellitus (DM) are likely to develop many types of infections, which affect the transport of glucose into tissues. Diabetes increases the susceptibility to different kinds of respiratory infections, is often identified as an ...
Renata Klekotka, Elżbieta Mizgała, W. Krol   +2 more
semanticscholar   +1 more source

A Phase 3 Multicenter, Double‐Blind Study Comparing Efficacy, Safety, Immunogenicity, and Pharmacokinetics of Alkem's Biosimilar Teriparatide Versus Reference Teriparatide in Postmenopausal Osteoporosis

AGING MEDICINE, EarlyView.
This phase III study demonstrated that Alkem's biosimilar teriparatide is noninferior to reference teriparatide in improving bone mineral density at the lumbar spine and femoral neck in postmenopausal osteoporosis patients, with comparable safety, pharmacodynamics, and immunogenicity profiles over 48 weeks of treatment.
Nitin Kapoor, Thomas Paul, Rajeshwar Nath Srivastava, Saurabh Singh, Sunil Maheshwari, Vishal Patil, Awadhesh Kumar Yadav, Girish Bhatia, Sushil H. Mankar, Joe Joseph Cherian, Surabhi Maheshwari, Sudeepti Srivastava, Dattatray Pawar, Roshan Pawar, Amol Aiwale, Amitrajit Pal, Yogesh Rane, Vinayaka Shahavi, Akhilesh Sharma   +18 more
wiley   +1 more source

Potential for Nirsevimab use in Pakistan

Journal of the Pakistan Medical Association
Respiratory Tract Infections can be classified as upper and lower tract infections. Upper tract infections are more common such as laryngitis and pharyngitis, but the infections of lower respiratory tract are more fatal such as influenza or bronchitis ...
Muhammad Moaz, Basum Hayat
doaj   +1 more source

Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia

Frontiers in Immunology, 2018
Influenza and other respiratory viral infections are the most common type of acute respiratory infection. Viral infections predispose patients to secondary bacterial infections, which often have a more severe clinical course.
Shigeo Hanada, Shigeo Hanada, Mina Pirzadeh, Mina Pirzadeh, Kyle Y. Carver, Kyle Y. Carver, Jane C. Deng, Jane C. Deng   +7 more
doaj   +1 more source

Cost-Effectiveness of Point-of-Care C-Reactive Protein Tests for Respiratory Tract Infection in Primary Care in England [PDF]

, 2015
Introduction Despite recommendations that general practitioners (GPs) delay antibiotic prescribing for respiratory tract infections (RTIs), antibiotic prescriptions in primary care in England increased by 4.1% from 2010 to 2013.
Hunter, R
core   +1 more source

Optimal duration of antimicrobial prophylaxis in patients undergoing distal pancreatectomy: A multicenter cohort study

Annals of Gastroenterological Surgery, EarlyView.
Prolonged administration of antimicrobial prophylaxis might not be effective to prevent surgical site infections after distal pancreatectomy compared to intraoperative or up to 24‐h administration. Abstract Background Antimicrobial prophylaxis is routinely administered in patients undergoing distal pancreatectomy, with cephalosporins being the most ...
Kenjiro Okada, Kenichiro Uemura, Sohei Satoi, Tsutomu Fujii, Manabu Kawai, So Yamaki, Toru Watanabe, Hideki Motobayashi, Shinya Takahashi   +8 more
wiley   +1 more source

Nasal colonization and lower respiratory tract infections with methicillin-resistant Staphylococcus aureus.

American Journal of Critical Care, 2015
BACKGROUND Methicillin-resistant Staphylococcus aureus is a cause of lower respiratory tract infections, particularly health care- and ventilator-associated pneumonia.
Belen Tilahun, Andrew C. Faust, Phyllis McCorstin, A. Ortegon   +3 more
semanticscholar   +1 more source

Palivizumab for the Prophylaxis of Respiratory Syncytial Virus Disease: Expert Opinion and Recommendations for the Gulf Cooperation Council Region

Oman Medical Journal
Respiratory syncytial virus (RSV) infection poses a significant health threat to infants and young children. Considering the substantial burden in Gulf Cooperation Council (GCC) countries, prevention of RSV remains a major public health priority ...
Adel S. Alharbi, Abdul Rahman Alnemri, Ahmed Abushahin, Entesar Alhammadi, Huda Sulaiman Mohammed AlDhanhani, Laila Obaid , Mahmoud Saleh ElHalik, Mariam Kh Ayed   +7 more
doaj   +1 more source

SELECTION PRINCIPLES OF INITIAL ETIOTROPIC THERAPY FOR ACUTE UPPER RESPIRATORY TRACT INFECTIONS IN CHILDREN

Медицинский совет, 2017
Acute upper respiratory tract infections maintain leadership in the overall morbidity patterns of the Russian Federation population. The highest prevalence of acute respiratory infections is reported in the pediatric population.
A. L. Zaplatnikov, A. A. Girina, E. I. Burtseva, I. V. Lepiseva, I. D. Maikova, N. V. Koroid, E. S. Kirillova, E. A. Mukashova, E. S. Oblogina   +8 more
doaj   +1 more source