Results 101 to 110 of about 9,888,914 (330)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Evaluating State Programmes - “Natural Experiments” and Propensity Scores [PDF]

Evaluations of programmes — for example, labour market interventions such as employment schemes and training courses — usually involve comparison of the performance of a treatment group (recipients of the programme) with a control group (non-recipients ...
Denis Conniffe, Vanessa Gash, Philip J. O'Connell   +2 more
core  

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Young in-Old out: a new evaluation based on Generalized Propensity Score [PDF]

This paper aims at evaluating the effect of the amount of older workers exits (aged 50 or more) on the entries of youngsters at a local labour market level, during years 1985 - 2002. If we can observe some effect of the exits on the entries, it will shed
Michela Bia, Roberto Leombruni, Pierre-Jean Messe   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Use of Propensity Scores in Non-Linear Response Models: The Case for Health Care Expenditures [PDF]

Under the assumption of no unmeasured confounders, a large literature exists on methods that can be used to estimating average treatment effects (ATE) from observational data and that spans regression models, propensity score adjustments using ...
Anirban Basu, Willard G. Manning, Daniel Polsky   +2 more
core  

Evacuating Flash Flood Victims: Key Drivers and Psychological Burden

Journal of Flood Risk Management
Effective, timely, and fair evacuation is crucial to mitigate flood impacts. We aim to identify socio‐economic attributes and flood event characteristics influencing evacuation and to quantify the psychological burden of people who experienced evacuation.
Nivedita Sairam, Doménica Michelle Jaramillo Sánchez, Lisa Dillenardt, Annegret H. Thieken   +3 more
doaj   +1 more source

Comparative effectiveness of metronidazole and vancomycin for treatment of Clostridioides difficile infection in hospitalized children

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: To compare rates of clinical response in children with Clostridioides difficile infection (CDI) treated with metronidazole vs vancomycin. Design: Retrospective cohort study was performed as a secondary analysis of a previously established ...
Thomas J. Sandora, Timothy J. Savage, Morgan E. Ryan, Suzanne E. Dahlberg, Kaitlyn Daugherty, Ciarán P. Kelly, Nira R. Pollock, Larry K. Kociolek   +7 more
doaj   +1 more source

Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease

Journal of Neuroinflammation, 2019
Background Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are related to several acquired demyelinating syndromes in adults, but the therapeutic approach is currently unclear. We aimed to describe the response to different therapeutic strategies
Alvaro Cobo-Calvo, María Sepúlveda, Fabien Rollot, Thais Armangué, Anne Ruiz, Elisabeth Maillart, Caroline Papeix, Bertrand Audoin, Helene Zephir, Damien Biotti, Jonathan Ciron, Francoise Durand-Dubief, Nicolas Collongues, Xavier Ayrignac, Pierre Labauge, Eric Thouvenot, Bertrand Bourre, Alexis Montcuquet, Mikael Cohen, Romain Deschamps, Nuria Solà-Valls, Sara Llufriu, Jerome De Seze, Yolanda Blanco, Sandra Vukusic, Albert Saiz, Romain Marignier   +26 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source