Results 91 to 100 of about 9,888,914 (330)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Parallel model-based and model-free reinforcement learning for card sorting performance
Scientific Reports, 2020 The Wisconsin Card Sorting Test (WCST) is considered a gold standard for the assessment of cognitive flexibility. On the WCST, repeating a sorting category following negative feedback is typically treated as indicating reduced cognitive flexibility ...
Alexander Steinke +2 more
doaj +1 more source
Neural Responses to Truth Telling and Risk Propensity under Asymmetric Information
PLOS ONE, 2015 Trust is multi-dimensional because it can be characterized by subjective trust, trust antecedent, and behavioral trust. Previous research has investigated functional brain responses to subjective trust (e.g., a judgment of trustworthiness) or behavioral trust (e.g., decisions to trust) in perfect information, where all relevant information is available
Hideo Suzuki +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Energies, 2018 This study aimed to investigate the change of consumer behavior in electric power consumption after the application of dynamic pricing via real-time feedback.
Thanh Tam Ho +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Consequences of Open Versus Closed Influence Strategies of Salespeople in a Developing Economy
Marketing Management Journal, 2011 The sales representatives of a pharmaceutical manufacturer in India were surveyed to explore the effects of influence strategies on customer oriented selling, adaptive selling, and sales performance, and to examine the relationships among sales ...
SUBHRA CHAKRABARTY +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Questionnaire Design and Response Propensities for Labour Income Microdata
, 2022 AbstractThe income question in household surveys is one of the most socially sensitive constructs. Two problems that arise with social sensitivity concern the probability of obtaining a response and the type of response provided. In survey error terms, this translates into an important relationship between questionnaire design (construct validity) and ...
openaire +1 more source
Investigation of asymmetric impulse responses between average consumption propensity and average food consumption propensity of household in Korea [PDF]
Agricultural Economics (Zemědělská ekonomika), 2019 Average consumption propensity (ACP) and average food consumption propensity (AFCP) are important indices for implementing macroeconomic and food policies. The present paper investigates the existence of asymmetric responses of ACP and AFCP to positive and negative shocks of each series in Korea.
openaire +2 more sources