Results 81 to 90 of about 9,888,914 (330)

On the Impact of Response Patterns on Survey Estimates from Access Panels

Survey Research Methods, 2013
Household and individual surveys increasingly gain importance in policy support and other areas. However, the raising number of surveys leads to reduced response rates.
Tobias Enderle, Ralf Münnich, Christian Bruch   +2 more
doaj   +1 more source

Synchronous population dynamics in California butterflies explained by climatic forcing [PDF]

Royal Society Open Science, 2017
A long-standing challenge for population biology has been to understand why some species are characterized by populations that fluctuate in size independently, while populations of other species fluctuate synchronously across space.
Nicholas A. Pardikes, Joshua G. Harrison, Arthur M. Shapiro, Matthew L. Forister   +3 more
doaj   +1 more source

Hydroxyurea responsiveness in  -thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity

Haematologica, 2012
β-thalassemia is caused by mutations in the β-globin locus resulting in loss of, or reduced, hemoglobin A (adult hemoglobin, HbA, α2β2) production. Hydroxyurea treatment increases fetal γ-globin (fetal hemoglobin, HbF, α2γ2) expression in postnatal life substituting for the missing adult β-globin and is, therefore, an attractive therapeutic approach ...
F. Pourfarzad, M. von Lindern, A. Azarkeivan, J. Hou, S. K. Kia, F. Esteghamat, W. van IJcken, S. Philipsen, H. Najmabadi, F. Grosveld   +9 more
openaire   +4 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Safety, efficacy, and response predictors of anticoagulation for the treatment of nonmalignant portal-vein thrombosis in patients with cirrhosis: a propensity score matching analysis

Clinical and Molecular Hepatology, 2014
Background/Aims Portal-vein thrombosis (PVT) develops in 10-25% of cirrhotic patients and may aggravate portal hypertension. There are few data regarding the effects of anticoagulation on nonmalignant PVT in liver cirrhosis.
J. Chung, G. Kim, Jong Ho Lee, K. Ok, E. Jang, S. Jeong, Jin-Wook Kim   +6 more
semanticscholar   +1 more source

Emotions and Actions Associated with Altruistic Helping and Punishment

Evolutionary Psychology, 2006
Evolutionary altruism (defined in terms of fitness effects) exists in the context of punishment in addition to helping. We examine the proximate psychological mechanisms that motivate altruistic helping and punishment, including the effects of genetic ...
Omar Tonsi Eldakar, David Sloan Wilson, Rick O'Gorman   +2 more
doaj   +1 more source

Self-organizing behaviors of cardiovascular cells on synthetic nanofiber scaffolds

APL Bioengineering, 2023
In tissues and organs, the extracellular matrix (ECM) helps maintain inter- and intracellular architectures that sustain the structure–function relationships defining physiological homeostasis.
Michael M. Peters, Jackson K. Brister, Edward M. Tang, Felita W. Zhang, Veronica M. Lucian, Paul D. Trackey, Zachary Bone, John F. Zimmerman, Qianru Jin, F. John Burpo, Kevin Kit Parker   +10 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Overall survival in response to sorafenib versus radiotherapy in unresectable hepatocellular carcinoma with major portal vein tumor thrombosis: propensity score analysis

BMC Gastroenterology, 2014
BackgroundThis study investigated the survival benefits of sorafenib vs. radiotherapy (RT) in patients with unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) in the main trunk or the first branch.MethodsNinety-seven ...
T. Nakazawa, H. Hidaka, A. Shibuya, Y. Okuwaki, Yoshiaki Tanaka, Juichi Takada, Tsutomu Minamino, Masaaki Watanabe, S. Kokubu, W. Koizumi   +9 more
semanticscholar   +1 more source