Results 71 to 80 of about 9,888,914 (330)

Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis

BMC Cancer, 2020
A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (NLR), in cancer recurrence and death has been
J. Mazaki, K. Katsumata, K. Kasahara, T. Tago, T. Wada, H. Kuwabara, M. Enomoto, T. Ishizaki, Y. Nagakawa, A. Tsuchida   +9 more
semanticscholar   +1 more source

Why Do Family Firms Hold Cash? Agency Conflicts and Valuation Perspectives

Risks
This study aims to examine whether family firms differ from nonfamily firms in their propensity to save cash, particularly in response to new investment opportunities, and to assess how investors value the cash holdings of family versus nonfamily firms ...
Ghada Tayem, Diana Abu-Ghunmi, Adel Bino, Mohammad Tayeh   +3 more
doaj   +1 more source

Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections

BJS Open, 2019
Background Preoperative oral antibiotics in addition to intravenous antibiotics and mechanical bowel preparation (MBP) may influence the gut microbiome and reduce both the postoperative systemic inflammatory response to surgery and postoperative ...
A. M. Golder, C. W. Steele, D. Conn, G. J. MacKay, D. C. McMillan, P. G. Horgan, C. S. Roxburgh, S. T. McSorley   +7 more
doaj   +1 more source

Factors Influencing the Propensity to Contract out Health and Human Services in Response to Government Cutbacks: Evidence from US Counties

Transylvanian Review of Administrative Sciences, 2019
Government agencies worldwide have faced budget cutbacks. Possible effects of budget cutbacks on the propensity to contract out have been discussed repeatedly; however, empirical evaluations are lacking.
Min-Hyu Kim
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Web Versus Other Survey Modes: An Updated and Extended Meta-Analysis Comparing Response Rates

Journal of Survey Statistics and Methodology, 2020
Do web surveys still yield lower response rates compared with other survey modes? To answer this question, we replicated and extended a meta-analysis done in 2008 which found that, based on 45 experimental comparisons, web surveys had an 11 percentage ...
Jessica Daikeler, M. Bošnjak, K. Manfreda   +2 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response

Journal of Hematology & Oncology, 2020
BackgroundThe propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of NETs in metastasis of hepatocellular carcinoma (HCC) and further ...
Luyu Yang, Qin Luo, Lu Lu, Wenwei Zhu, Haoran Sun, R. Wei, Zhifei Lin, Xiang-Yu Wang, Chaoqun Wang, Ming Lu, H. Jia, Jinhong Chen, Ju-bo Zhang, L. Qin   +13 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source