Results 41 to 50 of about 1,076,525 (264)
Applied Sciences, 2019 This study develops a modified multi-support response spectrum (MSRS) method, in order to efficiently and accurately calculate the response of multi-support structures under incoherent ground motions.
Jiyang Shen +3 more
doaj +1 more source
Open Geosciences, 2021 The thick soft superficial layers of the seabed greatly influence ground motion generally. It is worth studying how to find out the influence of these soft layers on ground motion parameters and determine reasonable seismic fortification parameters for ...
Jiang Qifeng +4 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Development of Seismic Demand for Chang-Bin Offshore Wind Farm in Taiwan Strait
Energies, 2016 Taiwan is located on the Pacific seismic belt, and the soil conditions of Taiwan’s offshore wind farms are softer than those in Europe. To ensure safety and stability of the offshore wind turbine supporting structures, it is important to assess the ...
Yu-Kai Wang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Dizhen xuebao为探究不同场地类别对反应谱特征周期的影响，建立了包含四种场地类别的180个计算剖面，在现行 《建筑抗震设计规范》 GB 50011—2010中场地分类的基础上按照土的软硬程度进一步细分，以不同幅值的El Centro地震动作为输入地震动，采用一维等效线性化方法进行土层反应分析，计算得到场地地震动反应谱，规准化得到反应谱特征周期。结果表明：① 在同一类别场地中，随着等效剪切波速的增大，特征周期呈减小的趋势；② 在同一类别场地中，随着输入地震动强度的增大，特征周期也相应增大；③ 在不同类别场地中 ...
Ping Li +5 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source