Results 51 to 60 of about 1,076,525 (264)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Soil Amplification and Code Compliance: A Case Study of the 2023 Kahramanmaraş Earthquakes in Hayrullah Neighborhood

Buildings
In the earthquakes that occurred in the Pazarcık (Mw = 7.7) and Elbistan (Mw = 7.6) districts of Kahramanmaraş Province on 6 February 2023, many buildings collapsed in the Hayrullah neighborhood of the Onikişubat district.
Eyübhan Avcı, Kamil Bekir Afacan, Emre Deveci, Melih Uysal, Suna Altundaş, Mehmet Can Balcı   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Seismic safety analysis of the Guazhou pump station

Nantong Daxue xuebao. Ziran kexue ban
The Guazhou pump station, a representative project awarded the Luban Prize, plays a crucial role in flood control and drainage in the urban area of Yangzhou.
WU Hao; LI Baochun; YUAN Cong; XIA Guochun; WU Yongjun; HUANG Kai; ZHANG Wei; QIU Jianchun
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Response spectra at elevations of station dam equipment installation

Magazine of Civil Engineering
The object of the study is a concrete station dam of a run-of-river hydroelectric power plant (HPP). A review of publications on the methods of calculating the dynamic responses of structures is presented.
Kozinetc Galina, Kozinetc Pavel, Badenko Vladimir   +2 more
doaj   +1 more source

Observations and analyses of site amplification effects of deep liquefiable soil deposits by geotechnical downhole array

Yantu gongcheng xuebao, 2017
Based on the accelerations recorded from two downhole arrays instrumented by the Caltrans/CDMG project, the site amplification effects of deep liquefiable soil deposits are analyzed in both time and frequency domains, and several important features of ...
ZHOU Yan-guo 1, 2, 3, TAN Xiao-ming 1, 2, 4, CHEN Jie 1, 2, PEI Xiang-jun 3, CHEN Yun-min 1, 2
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source