Results 51 to 60 of about 1,074,385 (267)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Fabrication and Performance of Single-crystal Diamond Neutron Detector with 6LiF Thermal Neutron Converter

Yuanzineng kexue jishu
Neutron detectors with excellent resolution, responsiveness, and radiation tolerance are desperately needed in the field of neutron monitoring. Diamond material has several advantages such as a wide bandgap, strong radiation tolerance, and high carrier ...
WANG Libin1, 2, ZHANG Yiyun3, LI Haijun2, MA Zhihai2, XI Shanxue2, LIU Huilan1, SONG Yushou1, , ZHOU Chunzhi2
doaj   +1 more source

ALTERNATIF DESAIN STRUKTUR GEDUNG MONUMEN DAN MUSEUM REOG PONOROGO DENGAN FRICTION PENDULUM SYSTEM

Jurnal Teknika
Kabupaten Ponorogo terletak di pantai selatan Jawa dan berbatasan dengan Kabupaten Pacitan di selatan, sering mengalami gempa bumi karena berada dekat zona aktif subduksi Lempeng Eurasia didorong ke utara oleh Lempeng Indo-Australia dengan kecepatan 50 ...
Hanisya Indah Mustika Hari, Ketut Aswatama Wiswamitra, Erno Widayanto, Krisnamurti, Dwi Nurtanto   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Response spectra at elevations of station dam equipment installation

Magazine of Civil Engineering
The object of the study is a concrete station dam of a run-of-river hydroelectric power plant (HPP). A review of publications on the methods of calculating the dynamic responses of structures is presented.
Kozinetc Galina, Kozinetc Pavel, Badenko Vladimir   +2 more
doaj   +1 more source

Observations and analyses of site amplification effects of deep liquefiable soil deposits by geotechnical downhole array

Yantu gongcheng xuebao, 2017
Based on the accelerations recorded from two downhole arrays instrumented by the Caltrans/CDMG project, the site amplification effects of deep liquefiable soil deposits are analyzed in both time and frequency domains, and several important features of ...
ZHOU Yan-guo 1, 2, 3, TAN Xiao-ming 1, 2, 4, CHEN Jie 1, 2, PEI Xiang-jun 3, CHEN Yun-min 1, 2
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source