Results 61 to 70 of about 1,076,525 (264)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Dizhen xuebao, 2020 基于美国NGA数据库，在断层投影距小于25 km范围内挑选了1387条地震加速度记录，分别按照断层距和场地条件进行分组，对近断层速度脉冲型地震动的频谱特性、特征周期，及其与断层距、震级的相关性予以分析。结果显示：① 出现速度脉冲型地震动的比例与断层投影距之间存在明显的线性相关关系，但其与震级的变化不相关；② 地震动速度脉冲周期与震级之间存在强相关；③ 对于近断层速度脉冲型地震动，采用动态变化的加速度和速度反应谱峰值周期进行特征周期的计算，更加符合真实情况；④ 地震动速度脉冲有放大地震动特征周期的作用 ...
Ruifang Yu +4 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Incorporation of rubber-steel bearing isolation in multi-storey muilding
Journal of Civil Engineering and Management, 2014 Base isolation incorporation has moved towards a popular technology in the seismic vulnerable regions. The system mitigates lateral action of tremor hazard providing flexibility of structures.
A. B. M. Saiful Islam +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Shock Response Spectrum Analysis of Fatigued Runners. [PDF]
Sensors (Basel), 2022 Benjamin D +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Response Spectrum Analysis of Response of Building with Setbacks
IOSR Journal of Mechanical and Civil Engineering, 2016 The past earthquakes have shown catastrophic effect on the buildings with irregularities. It was seen that the buildings with irregularities are more prone to earthquake then the regular building. The structure with irregularities are called irregular structures.
openaire +1 more source