Results 81 to 90 of about 2,569,579 (302)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The scalar perturbation spectral index n_s: WMAP sensitivity to unresolved point sources [PDF]
, 2007 Precision measurement of the scalar perturbation spectral index, n_s, from the Wilkinson Microwave Anisotropy Probe temperature angular power spectrum requires the subtraction of unresolved point source power. Here we reconsider this issue.
A. J. Banday +5 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Criteria for vibration testing [PDF]
, 1971 Systematic application of response spectral analysis and other analyses determine damping sensitivity of flight environment and candidate laboratory tests.
Cronin, D. L.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Seismic Effects on a Horizontally Unsymmetrical Building using Response Spectrum Analysis
MATEC Web of Conferences, 2018 Most of the residential buildings in Malaysia are not designed to withstand the seismic forces, while the high-rise buildings. However, since the Sumatra 2004 earthquake, there had been increasing concerns about the structure vulnerability in our country
Nizamani Zafarullah +4 more
doaj +1 more source
Energies, 2020 In this paper, the dynamic responses of a large-scale multiple-support road viaduct to mining-induced seismic events registered in two regions of mining activity were compared. The regions differ in geological structure, which results in discrepancies in
Paweł Boroń +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Response Spectrum Analysis of the Domestic Piston of Reciprocating Compressor Based on ANSYS
Shiyou jixie, 2017 To evaluate the working performance of the domestic piston on reciprocating compressor, taking the crankshaft connecting-rod movement to the dead point as study object, analyses on the modal and response spectrum of the piston and piston rod have been ...
Duan Lixiang +4 more
doaj