Results 91 to 100 of about 2,569,579 (302)

Dynamic characteristics assessment of reactor vessel internals with fluid-structure interaction

Nuclear Engineering and Technology, 2017
Improvement of numerical analysis methods has been required to solve complicated phenomena that occur in nuclear facilities. Particularly, fluid-structure interaction (FSI) behavior should be resolved for accurate design and evaluation of complex reactor
Sang Yun Je, Yoon-Suk Chang, Sung-Sik Kang   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Introducing Adaptive Incremental Dynamic Analysis: A New Tool for Linking Ground Motion Selection and Structural Response Assessment [PDF]

, 2013
Adaptive Incremental Dynamic Analysis (AIDA) is a novel ground motion selection scheme that adaptively changes the ground motion suites at different ground motion intensity levels to match hazardconsistent properties for structural response assessment ...
Baker, Jack W., Lin, Ting
core   +1 more source

Systematic Effects of Foreground Removal in 21cm Surveys of Reionization [PDF]

, 2011
It is well-known that foreground subtraction in 21cm surveys removes large scale power. We investigate associated systematic biases. We show that removing line-of-sight fluctuations on large scales aliases into suppression of the 3D power spectrum across
Anantharamaiah, Anantharamaiah, Banday, Boissier, Bond, Bowman, Colberg, Datta, Di Matteo, Di Matteo, Furlanetto, Furlanetto, Geil, Geil, Gleser, Gnedin, Gordon, Harker, Harker, Ichikawa, Jelić, Jelić, Kaiser, Lacey, Lawson, Lidz, Lidz, Liu, Liu, McQuinn, Mesinger, Mesinger, Morales, Morales, Morales, Nada Petrovic, Oh, Roy, Roy, Rybicki, Rybicki, S. Peng Oh, Santos, Seaquist, Shaver, Shaver, Shaver, Shioya, Tegmark, Wang, Wyithe, Young, Yun, Zaldarriaga, Zhao   +54 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A non-separable stochastic model for pulse-like ground motions [PDF]

, 2013
A phenomenological non-separable non-stationary stochastic model is proposed to represent near-fault pulse-like ground motions (PLGMs) by means of a parametrically defined evolutionary power spectrum (EPSD). Numerical data pertaining to ensembles of EPSD
Giaralis, A., Lungu, A.
core  

Sky reconstruction from transit visibilities: PAON-4 and Tianlai Dish Array

, 2016
The spherical harmonics $m$-mode decomposition is a powerful sky map reconstruction method suitable for radio interferometers operating in transit mode. It can be applied to various configurations, including dish arrays and cylinders.
Ansari, Reza, Campagne, Jean-Eric, Chen, Xuelei, Magneville, Christophe, Wu, Fengquan, Zhang, Jiao   +5 more
core   +3 more sources

DASI First Results: A Measurement of the Cosmic Microwave Background Angular Power Spectrum [PDF]

, 2002
We present measurements of anisotropy in the Cosmic Microwave Background (CMB) from the first season of observations with the Degree Angular Scale Interferometer (DASI).
Carlstrom, J. E., Cartwright, J. K., Dragovan, M., Halverson, N. W., Holzapfel, W. L., Kovac, J., Leitch, E. M., Mason, B. S., Padin, S., Pearson, T. J., Pryke, C., Readhead, A. C. S., Shepherd, M. C.   +12 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source