Results 111 to 120 of about 2,257,568 (316)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

On the response of coaxial surface thermocouples for transient aerodynamic heating measurements

, 2017
Surface thermocouples are widely used in transient aerodynamic heating measurements but their response often exhibits uncertainty and unpredictability resulting in poor accuracy of measurement. To address this issue and provide reference information on
李进平, Chen, H (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab High Temp Gas Dynam, Beijing 100190, Peoples R China., 张仕忠, 陈宏, 张晓源, 俞鸿儒   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Optimization of extraction process of polysaccharides from mulberry leaves and determination of the antioxidant activity in vitro

Shipin yu jixie
ObjectiveThis study aimed to optimize the extraction process of polysaccharides from mulberry leaves using deep eutectic slovents (DES) and assess their antioxidant properties.MethodsAutumn mulberry leaf powder was used as the raw material, and ...
WU Jun, YANG Biwen, ZHAO Pei, MA Jingqiu, WANG Xiaojing, HUANG Yue   +5 more
doaj   +1 more source

Development of advanced Cu and Ni temperature sensors on ceramic-coated tubes via electroless plating

Publisher Copyright: © 2025 Elsevier B.V.Considering the high cost of precious elements, it is necessary to replace metals like platinum or gold in the sensor sector.
Brizuela, Marta, Dominguez, Santiago, Astigarraga, Victoria, Bikarregi, Aitor, López, Alejandra, López, Gabriel A.   +5 more
core   +1 more source

MODELING THE POTENTIAL HAZARD OF WATER EROSION OF SOILS

Мелиорация и гидротехника
Purpose: to create digital models of water erosion factors in the form of parametric response surfaces and systems of point equations and to determine functional links between them and the geometric parameters of the micro- and nanorelief of a soil ...
Alexander I. Karaiev, Lyudmila N. Tolstolik, Stanislav Y. Radev   +2 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Response-Surface Methods in R, Using rsm

This article describes the recent package rsm, which was designed to provide R support for standard response-surface methods. Functions are provided to generate central-composite and Box-Behnken designs.
Russell V. Lenth
core  

The effects of machining process variables and tooling characterisation on the surface generation: modelling, simulation and application promise

, 2005
The paper presents a novel approach for modelling and simulation of the surface generation in the machining process. The approach, by integrating dynamic cutting force model, regenerative vibration model, machining system response model and tool profile ...
Cheng, K, Luo, X, Ward, R
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source