Results 111 to 120 of about 4,922,205 (297)

MODELING THE POTENTIAL HAZARD OF WATER EROSION OF SOILS

Мелиорация и гидротехника
Purpose: to create digital models of water erosion factors in the form of parametric response surfaces and systems of point equations and to determine functional links between them and the geometric parameters of the micro- and nanorelief of a soil ...
Alexander I. Karaiev, Lyudmila N. Tolstolik, Stanislav Y. Radev   +2 more
doaj   +1 more source

Influência das variáveis nitrogênio, fósforo e ºBrix na produção dos metabólicos secundários contaminantes totais da fermentação alcoólica Influence of nitrogen, phosphorus and ºBrix on the production of total secondary contaminant metabolites (MSCT) of alcoholic fermentation

Química Nova, 2006
The present study evaluated the influence of nitrogen, phosphorus and ºBrix on the production of MSCT through a factorial design methodology and analysis of response surface.
José Alexsandro Silva, Flávio Luiz Honorato da Silva, Rômulo Romeu da Nóbrega Alves, Davi Pereira de Santana   +3 more
doaj   +1 more source

Amplification and Increased Duration of Earthquake Motion on Uneven Stress-Free Ground

, 2006
When a flat stress-free surface (i.e., the ground in seismological applications) separating air from a isotropic, homogeneous or horizontally-layered, solid substratum is solicited by a SH plane body wave incident in the substratum, the response in the ...
Groby, Jean-Philippe, Wirgin, Armand
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Collaborative Optimization Method of Structural Lightweight Design Integrating RSM-GA for an Electric Vehicle BIW

World Electric Vehicle Journal
The body-in-white (BIW) is an important part of the electric vehicle body, its mass accounts for about 30% of the vehicle mass, and reducing its mass can significantly contribute to energy savings and emission reduction.
Hongjiang Li, Shijie Sun, Hong Fang, Xiaojuan Hu, Junjian Hou, Yudong Zhong   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source