Results 91 to 100 of about 2,257,568 (316)

Identification of critical parameters of cell transition from the state of proliferation to the state of differentiation

Біологічні студії, 2014
This paper describes by mathematical modeling changes in the genetic control of cell in a state of proliferation and differentiation. It was constructed seventeen response surfaces for each of the speed rate constants that characterize the ...
I. V. Stadnyk, D. I. Sanagursky
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Triggering thresholds and influential factors in the propagation of meteorological drought to hydrological drought

Journal of Hydrology: Regional Studies
Study regions: The Huaihe River Basin (HRB), China Study focus: Quantifying the thresholds for the systematic propagation of meteorological drought (MD) to different levels of hydrological drought (HD) is essential for early warning and precision ...
Na Zhen, Rui Yao, Peng Sun, Qiang Zhang, Chenhao Ge, Han Shen   +5 more
doaj   +1 more source

Optimization of energy consumption of a solar-electric dryer during hot air drying of tomato slices

Journal of Agricultural Engineering, 2019
High-energy demand of convective crop dryers has prompted study on optimization of dryer energy consumption for optimal and cost effective drying operation. This paper presents response surface optimization of energy consumption of a solar-electric dryer
Nnaemeka R. Nwakuba
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Two-Step Reconstruction Framework for Mapping Seamless All-Weather Daily Evapotranspiration Using Thermal Infrared Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Spatio-temporally continuous daily evapotranspiration (ET) is essential for characterizing water and energy exchange and scheduling efficient water management.
Gengle Zhao, Long Zhao, Lisheng Song, Hua Wu, Qiaoyun Xie, Shaomin Liu, Kejia Xue, Sinuo Tao, Penghai Wu, Lingfeng Zhang   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploiting correlation in the construction of D-optimal response surface designs. [PDF]

Cost considerations and difficulties in performing completely randomized experiments often dictate the necessity to run response surface experiments in a bi-randomization format.
Goos, Peter, Vandebroek, Martina
core  

DESIGN AND TESTING OF A CASSAVA HARVESTER DIGGING SHOVEL BASED ON THE DISCRETE ELEMENT AND RESPONSE SURFACE METHODS

Engenharia Agrícola
In light of the problems of large operation resistance and small soil fragmentation during the harvesting operations of existing cassava harvesters, a long- and short-toothed digging shovel was designed.
Liao Yulan, Pan Xiang, Huang Long, Guo Daigui, Wu Zhenpeng   +4 more
doaj   +1 more source

Structural Optimization of Stage Cementing Collar Based on the Response Surface Methodology

Shiyou jixie, 2023
The structural stiffness of the stage cementing collar cannot meet the requirement during applications,and the sliding sleeve often fails to open or close ports,due to structural deformation.Given this,the optimization of five key dimension parameters of
Xu Ruiqiang, Sun Xingwei, Liu Yin, Yang Heran, Dong Zhixu   +4 more
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