Results 71 to 80 of about 2,257,568 (316)

Optimization of xylanase production by Thermomyces lanuginosus in tomato seed meal using response surface methodology

, 2006
A 32 central composite experimental design was performed with the aim of optimizing xylanase production by Thermomyces lanuginosus grown on corn cobs in submerged cultures.
Katapodis, P, Christakopoulos, P, Christakopoulou, V, Christakopoulos, Paul, Katapodis, Petros,, Christakopoulou, Vasiliki,   +5 more
core   +1 more source

Estimation of agricultural flood irrigation water consumption in the Heihe River Basin, China, using satellite based daily land surface evapotranspiration and soil moisture

Journal of Hydrology: Regional Studies
Study region: The Heihe River Basin, China. Study focus: Irrigation data are often from census surveys at coarse administrative or river basin scale, and as such, the amount of water used for agricultural irrigation difficult to quantify.
Lirong Huo, Qiaoyun Xie, Liang Sun, Lisheng Song, Sinuo Tao, Shaomin Liu, Zuo Wang, Yan Li   +7 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Surface heat flux parameterization and the response of ocean general circulation models to high-latitude freshening [PDF]

, 1994
A global ocean general circulation model (OGCM) is forced using mixed boundary conditions (i.e. a restoring condition on the upper level temperature but using a fixed, specified surface salt flux).
Power, S. B., Kleeman, R.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

High-resolution hot-film measurement of surface heat flux to an impinging jet

, 2011
To investigate the complex coupling between surface heat transfer and local fluid velocity in convective heat transfer, advanced techniques are required to measure the surface heat flux at high spatial and temporal resolution.
T S O'Donovan, O'Donovan, T. S.; id_orcid, D B Murray, Murray, D. B., T Persoons, Persoons, T.   +5 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

An algorithm for generating response surface split-plot designs

, 2012
M.PhilIn an industrial experiment, the presence of hard-to-change factors may force the experimenter to use a split-plot type experimental structure. The corresponding Response Surface model then is a linear mixed model. Different design methodologies
Khadim, Mudakkar Mnas
core  

A Spatial-Temporal Seamless Evapotranspiration Product Based on TSEB-SM Model and DNN-ETo Method Across China

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Accurate, seamless products of evapotranspiration (ET) are crucial for understanding the hydrological and energy cycles. Currently, there is no routinely available daily ET product based on the thermal infrared satellite data and two-source energy ...
Gengle Zhao, Lisheng Song, William P. Kustas, Long Zhao, Shaomin Liu, Gaofei Yin, Rongqi Tang   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source