Results 81 to 90 of about 2,257,568 (316)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The magnitudes and timescales of global mean surface temperature feedbacks in climate models [PDF]
, 2011 Because of the fundamental role feedbacks play in determining the response of surface temperature to perturbations in radiative forcing, it is important we understand the dynamic characteristics of these feedbacks.
A. Jarvis, Jarvis, Andrew
core +1 more source
Optimization of the seed medium of Lactobacillus casei GJ00412 isolated from soy whey
Liang you shipin ke-ji, 2020 Soy whey (SW) is generated as a process waste during soy isolate protein preparation. SW has low content of soluble sugar and high content of oligosaccharide, which is suitable for the growth of lactic acid bacteria (LAB).
HAN Wei +7 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
, 2006 Static pore water pressures in confined aquifers vary in response to ground surface loading changes, including precipitation and evaporation. Under certain hydrogeological conditions such aquifers can function as giant natural weighing lysimeters ...
Sophocleous, Marios +2 more
core +1 more source
Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules [PDF]
, 2009 It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but also to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously
Tsortos, Achilleas +13 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Heavy Rainfall Increases CO2 Emissions from Rivers in a Typical Human-Impacted Region
AtmosphereRivers emit substantial amounts of carbon dioxide (CO2) to the atmosphere, yet its response to heavy rainfall remains unclear with intensive anthropogenic disturbances.
Zhijie Gao +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2005 Aims: To optimize cholesterol removal by Lactobacillus acidophilus ATCC 4962 in the presence of prebiotics, and study the growth and fermentation patterns of the prebiotics.
Liong, Min Tze +3 more
core +1 more source