Results 101 to 110 of about 4,922,205 (297)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The vortex depinning transition in untwinned YBaCuO using complex impedance measurements

, 2003
We present surface impedance measurement of the vortex linear response in a large untwinned YBCO crystal. The depinning spectra obtained over a broad frequency range (100 Hz- 30 MHz) are those of a surface pinned vortex lattice with a free flux flow ...
A. Pautrat, A.I. Rykov, Alais, B. Andrewjewski, C. Goupil, Campbell, Ch. Simon, Lütke-Entrup, Pautrat, Pautrat, S. Tajima, Sonin, Volovik   +12 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Strength and durability of concrete with bentonite clay and quarry dust

Frontiers in Materials
The research object is concrete with supplementary cementitious materials (SCMs) such as bentonite clay and quarry dust. The impact of incorporating these SCMs on fresh concrete properties, compressive, flexural, and split tensile strengths, and acid ...
Muhammad Umar, Hui Qian, M. Nasir Ayaz Khan, Muhammad Shahid Siddique, Hamad Almujibah, Ali. E. A. Elshekh, Maaz Osman Bashir, Nikolai Ivanovich Vatin   +7 more
doaj   +1 more source

Anomalous conductivity, Hall factor, magnetoresistance, and thermopower of accumulation layer in $\text{SrTiO}_3$

, 2016
We study the low temperature conductivity of the electron accumulation layer induced by the very strong electric field at the surface of $\text{SrTiO}_3$ sample.
Fu, Han, Reich, K. V., Shklovskii, B. I.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Optimization of extraction process of polysaccharides from mulberry leaves and determination of the antioxidant activity in vitro

Shipin yu jixie
ObjectiveThis study aimed to optimize the extraction process of polysaccharides from mulberry leaves using deep eutectic slovents (DES) and assess their antioxidant properties.MethodsAutumn mulberry leaf powder was used as the raw material, and ...
WU Jun, YANG Biwen, ZHAO Pei, MA Jingqiu, WANG Xiaojing, HUANG Yue   +5 more
doaj   +1 more source

Response-Surface Methods in R, Using rsm [PDF]

This article describes the recent package rsm, which was designed to provide R support for standard response-surface methods. Functions are provided to generate central-composite and Box-Behnken designs.
Russell V. Lenth
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Randomized response surface pathway design with odd response outcomes in a Latin Square designed study

Open Access Journal of Clinical Trials, 2017
Trond Holand,1 Kristian Ellingsen,2 Sagita Dewi,1,3 Stig Larsen1 1Centre for Epidemiology and Biostatistics, Department of Production Animal Clinical Sciences, Faculty of Veterinary Science, Norwegian University of Life Science, 2Norwegian Veterinary ...
Holand T, Ellingsen K, Dewi S, Larsen S
doaj