Results 71 to 80 of about 15,971,534 (326)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Nanometer scale titanium surface texturing are detected by signaling pathways involving transient FAK and Src activations. [PDF]
PLoS ONE, 2014 BACKGROUND:It is known that physico/chemical alterations on biomaterial surfaces have the capability to modulate cellular behavior, affecting early tissue repair.
Willian F Zambuzzi +9 more
doaj +1 more source
On some aspects of second order response surface methodology : a thesis presented in partial fulfilment of the requirements for the degree of M. Sc. in Mathematics at Massey University [PDF]
, 1972 A unified development of the theoretical basis of response surface methodology, particularly as it applies to second order response surfaces, is presented.
Thomas, Vernon John
core
, 1999 Extending our previous work we classify the nonlinear magneto-optical response at low index surfaces of fcc antiferromagnets, such as NiO. Antiferromagnetic bilayers are discussed here as models for the termination of bulk antiferromagnets.Comment: 7 ...
Hübner, W., Trzeciecki, M.
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Fitting functional response surfaces to data: a best practice guide
Ecosphere, 2020 Describing how resource consumption rates depend on resource density, conventionally termed “functional responses,” is crucial to understanding the population dynamics of trophically interacting organisms.
Wojciech Uszko +2 more
doaj +1 more source
Horizon energy and angular momentum from a Hamiltonian perspective
, 2005 Classical black holes and event horizons are highly non-local objects, defined in terms of the causal past of future null infinity. Alternative, (quasi)local definitions are often used in mathematical, quantum, and numerical relativity.
Arnold V I +18 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Gas Metal Arc /GMA/ weld torch proximity control [PDF]
, 1969 Adjustable transducer probe, which is attached to a welding torch and maintains a preset touch-to-work distance, accurately follows irregular surfaces, is less sensitive to heat and static interference, and has more positive response because of electro ...
Hawkes, E. D.
core +1 more source