Results 61 to 70 of about 450,805 (266)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Efecto de la presión de vacío, sólidos solubles totales y tiempo de procesamiento sobre la deshidratación osmótica de rebanadas de melón Effect of the pressure of vacuum, total soluble solids and processing time on the osmotic dehydration of slices of melon

Bioagro, 2010
Se estudió la deshidratación osmótica de rebanadas de melón (Cucumis melo L.) como alternativa para la obtención de productos secos con características similares a los frescos, y que demanden menos energía para su estabilización, almacenamiento y ...
Luis Chaparro, Naudy Soto, Tonny García, Julio Gutiérrez, Jhonny Palmero   +4 more
doaj  

Analysis of the Cellular Response to Different Dental Implant Surfaces: An In vitro Study

Journal of Pharmacy and Bioallied Sciences
Background: Dental implant surfaces play a crucial role in determining the success of osseointegration and long-term stability. Understanding the cellular response to various implant surfaces is essential for optimizing implant design and clinical ...
Mohammed G. Sghaireen, Mohammad Raji Alrwuili, Nasser Attallah Alenzi, Mohammed Ahmed Aljabab, Rakhi Issrani, Mohammad Khursheed Alam   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Response Surfaces in the Numerical Homogenization of Non-Linear Porous Materials

Engineering Transactions, 2019
The paper deals with the numerical homogenization of structures made of non-linear porous material. Material non-linearity causes a significant increase in computational costs for numerical homogenization procedure. An application of the response surface
Witold BELUCH, Marcin HATŁAS
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

In Vitro Analysis of Bone Response to Different Implant Surface Roughness

Journal of Pharmacy and Bioallied Sciences
Background: The surface roughness of dental implants plays a critical role in osseointegration by enhancing bone-implant contact. However, the optimal surface topography to maximize bone response is still under investigation.
Sushma Sanjay Lagdive, Amit Vasani, Vibhuti Madhad, Satinder Pal Singh Tulsi, Abikshyeet Panda, Satya Prakash Gupta, Hiren Hansraj Patadiya, Honey Lunkad   +7 more
doaj   +1 more source