Results 71 to 80 of about 6,785,013 (298)
Using ensemble climate projections to assess probabilistic hydrological change in the Nordic region [PDF]
Natural Hazards and Earth System Sciences, 2011 Assessing hydrological effects of global climate change at local scales is important for evaluating future hazards to society. However, applying climate model projections to local impact models can be difficult as outcomes can vary considerably between ...
F. Wetterhall +4 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Geriatrics, Gerontology and Aging, 2023 Objective: To compare the affective response of postmenopausal women who undergo 6 weeks of resistance training on stable and unstable surfaces. Methods: This andomized counterbalanced cross-over study carried included 14 postmenopausal women (55 [SD, 3]
Danielle Cristhiane de Lira +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering Reports, 2023 This paper presents a framework combining Monte Carlo Simulation (MCS) and the Newmark sliding block model with representative slip surfaces (RSS) (model II) and multiple response surfaces method (MRSM) to conduct seismic reliability analysis and risk ...
Guangming Yu +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Response surfaces of the factors’ influence of damage rate.
, 2022 Response surfaces of the factors’ influence of damage rate.
Ni Wang (457382) +6 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Acknowledgment to Reviewers of Surfaces in 2020
, 2021 Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Surfaces maintains its standards for the high quality of its published papers [...
Surfaces Editorial Office Surfaces Editorial Office +2 more
core +2 more sources