Results 121 to 130 of about 2,903,331 (254)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Bayesian Joint Modeling of Response Times with Dynamic Latent Ability in Educational Testing. [PDF]

Psychometrika
Wang X, Saha A, Dey DK.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries. [PDF]

BMC Glob Public Health
Delport D, Muellenmeister AM, Greig J, Abeysuriya RG, Scott N.   +4 more
europepmc   +1 more source

Moving beyond response times with accessible measures of manual dynamics. [PDF]

Sci Rep, 2022
Smith KA, Morrison S, Henderson AME, Erb CD.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Impact of Snowfall on Ambulance Response Times to Out-of-Hospital Cardiac Arrest　- Nationally-Representative Population-Based Registry Analysis, 2009-2019. [PDF]

Circ Rep
Wataki H, Seposo XT, Uttajug A, Anzai T, Yokota I, Ueda K, Yonemoto N, Tahara Y, Matoba T, Ikeda T, Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Investigators.   +10 more
europepmc   +1 more source

Performance-linked visual feedback slows response times during a sustained attention task. [PDF]

Cogn Res Princ Implic, 2023
Steinkrauss AC, Shaikh AF, O'Brien Powers E, Moher J.   +3 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Association of ambulance and helicopter response times with patient survival: A systematic literature review and meta-analysis. [PDF]

PLoS One
Hansen PM, Nielsen MS, Rehn M, Lassen A, Perner A, Mikkelsen S, Brøchner AC.   +6 more
europepmc   +1 more source