Results 121 to 130 of about 2,908,176 (252)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Bayesian Joint Modeling of Response Times with Dynamic Latent Ability in Educational Testing. [PDF]

Psychometrika
Wang X, Saha A, Dey DK.
europepmc   +1 more source

Moving beyond response times with accessible measures of manual dynamics. [PDF]

Sci Rep, 2022
Smith KA, Morrison S, Henderson AME, Erb CD.   +3 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries. [PDF]

BMC Glob Public Health
Delport D, Muellenmeister AM, Greig J, Abeysuriya RG, Scott N.   +4 more
europepmc   +1 more source

Performance-linked visual feedback slows response times during a sustained attention task. [PDF]

Cogn Res Princ Implic, 2023
Steinkrauss AC, Shaikh AF, O'Brien Powers E, Moher J.   +3 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of Snowfall on Ambulance Response Times to Out-of-Hospital Cardiac Arrest　- Nationally-Representative Population-Based Registry Analysis, 2009-2019. [PDF]

Circ Rep
Wataki H, Seposo XT, Uttajug A, Anzai T, Yokota I, Ueda K, Yonemoto N, Tahara Y, Matoba T, Ikeda T, Japanese Circulation Society with Resuscitation Science Study (JCS-ReSS) Investigators.   +10 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Association of ambulance and helicopter response times with patient survival: A systematic literature review and meta-analysis. [PDF]

PLoS One
Hansen PM, Nielsen MS, Rehn M, Lassen A, Perner A, Mikkelsen S, Brøchner AC.   +6 more
europepmc   +1 more source