Ambulance response times - improved communication between clinical teams may offer a solution. [PDF]
Br J Gen Pract, 2022 Rudland SV, Bushaway R.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Location-based response times of emergency physicians in rural Germany: an observational study. [PDF]
BMC Emerg MedRaker M, Weilbach C, Scharonow M.
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Repeated unilateral handgrip contractions alter functional connectivity and improve contralateral limb response times. [PDF]
Sci Rep, 2023 Andrushko JW +8 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Understanding EMS response times: a machine learning-based analysis. [PDF]
BMC Med Inform Decis MakHill P +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
A sparse latent class model incorporating response times. [PDF]
Br J Math Stat PsycholHe S, Culpepper SA, Douglas JA.
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Capturing trial-by-trial variability in behaviour: people with Parkinson's disease exhibit a greater rate of short-term fluctuations in response times. [PDF]
Transl PsychiatryMacDonald HJ +3 more
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