Results 71 to 80 of about 5,192,011 (281)

Responsibility modulates neural mechanisms of outcome processing : an ERP study

, 2011
The role of personal responsibility in decision-making and its influence on the outcome evaluation process have been investigated relatively rarely in cognitive neuroscience.
Han, Chunhui, Holroyd, Clay, Lei, Yi, Li, Hong, Li, Peng   +4 more
core   +1 more source

Responsibility modelling for civil emergency planning [PDF]

, 2009
This paper presents a new approach to analysing and understanding civil emergency planning based on the notion of responsibility modelling combined with HAZOPS-style analysis of information requirements. Our goal is to represent complex contingency plans
A Aviz̆ienis, C Perrow, CM Pearson, D Martin, D Martin, D Smith, D Smith, D Smith, DM Woods, E Mumford, G Dewsbury, I Sommerville, Ian Sommerville, J Dobson, J Reason, JA McDermid, P Checkland, R Darimont, R Strens, RJ Wieringa, Russell Lock, S Kholsa, Tim Storer   +22 more
core   +4 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

“Morals and ethics and law, oh my!” – an historical perspective on the aba model rules of professional conduct

Baltic Journal of Law & Politics, 2013
This paper discusses the tensions between moral obligations, ethical rules and legal requirements contained within the American Bar Association Model Rules of Professional Conducts by reviewing the history and evolution of the Model Rules and the ...
Rendleman Dennis A.
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

God and moral responsibility [PDF]

, 2011
I will argue in this article that Scheler’s last writings are not necessarily less valuable than his earlier works. First, I will try to prove that Scheler’s Späte Schriften are in concordance with his earlier writings, at least from the perspective of ...
Gescinska, Alicja Anna
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Farm Fresh Healthcare Project: Analysis of a Hybrid Values-based Supply Chain

Journal of Agriculture, Food Systems, and Community Development, 2016
An emerging literature on values-based supply chains offers models for meeting both the scale-based requirements and values-based goals of farm-to-institution initiatives.
Kendra Klein, Ariane Michas
doaj   +1 more source