Results 41 to 50 of about 2,414,155 (290)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
‘FLEXIBLE’ BUDGETS ARE ALREADY BUDGETING PROCESS ANALYSIS OF PRODUCTION COSTS FOR OIL AND FAT ENTERPRISES [PDF]
Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2013 The problems of methodological fundamentals of managerial accounting of manufacturing costs in information provision for budgeting, not only at the enterprise level, but also as it is required by current conditions of advanced control, in the context of ...
V. Shvetz’, E. Mykhalska
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Reliability Analysis of N -policy Vacation-Based FTC System Subject to Standby Switching Failures [PDF]
Operations Research and Decisions, 2023 The paper is aimed to investigate the reliability metrics of a multi-unit fault-tolerant control (FTC) system wherein the units are subject to failure and those are repairable by two heterogeneous servers.
Sudeep Kumar, Ritu Gupta
doaj
Causal Responsibility and Counterfactuals. [PDF]
, 2013 How do people attribute responsibility in situations where the contributions of multiple agents combine to produce a joint outcome? The prevalence of over-determination in such cases makes this a difficult problem for counterfactual theories of causal ...
Lagnado, DA, Zultan, R, Gerstenberg, T
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Responsibility without Guilt: A Youngian Approach to Responsibility for Global Injustice [PDF]
, 2015 What responsibilities do individuals have in relation to global injustice? Iris Young argues that all agents “connected” to global structural injustice bear political responsibility, rather than moral responsibility; the difference being that political ...
McKeown, MC
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Diminished responsibility as a defence in Ireland having regard to the law in England, Scotland and Wales. [PDF]
, 1996 This thesis is an inquiry into the necessity of a diminished responsibility defence in Irish law. The inquiry examines the controversy surrounding each attempt to reformulate the insanity defence in the Anglo-American world.
Boland, Faye
core +4 more sources