Results 61 to 70 of about 25,873 (260)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Work and Lives in Makassar Coastal Community: Assessing the Local Government Policy

Hasanuddin Law Review, 2020
The Makassar City Regional Government formulated a policy that previously carried out Mapping conducted on the less prosperous Coastal community, so departing from the mapping results obtained then formulated a policy as in the development of human ...
Iin Karita Sakharina, Aidir Amin Daud, Muh. Hasrul, Kadarudin Kadarudin, Hasbi Assidiq   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Global fisheries sustainability performance data collected from pre-assessments against the Marine Stewardship Council’s fisheries standardZenodo

Data in Brief
The Marine Stewardship Council (MSC) is an international non-profit organization that sets a Fisheries Standard [1] for environmentally sustainable fishing, based on the Food and Agriculture Organization (FAO) of the United Nations’ Code of Conduct for ...
Jennifer Rasal, Michael C. Melnychuk, Sophie Ferber, Amanda Lejbowicz, Carlos Montero-Castaño, Catherine Longo   +5 more
doaj   +1 more source

Do responsible fishing areas work? Comparing collective action challenges in three small-scale fisheries in Costa Rica

International Journal of the Commons, 2019
Costa Rica is supporting Marine Areas of Responsible Fishing (AMPRs) to enable small-scale fishing communities to apply for exclusive harvesting and management rights within spatially delimited areas under a co-management policy framework.
Isis Ivania Chavez Carrillo, Stefan Partelow, Roger Madrigal-Ballestero, Achim Schlüter, Isabel Gutierrez-Montes   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ANALISIS ECOLOGICAL FOOTPRINT SISTEM PERIKANAN DI KAWASAN TAMAN WISATA PERAIRAN GILI MATRA, LOMBOK UTARA

Jurnal Ilmu Pertanian Indonesia, 2014
Gili Matra Aquatic Park is a conservation area located in Gili Indah Village, North Lombok. It is one of marineprotected areas that has a wide range of potential resources, i.e. fish resources and ecosystems.
Made Ayu Pratiwi, Yusli Wardiatno, Luky Adrianto   +2 more
doaj  

Identification of environmentally friendly of technology fishing gears in Bireuen District

Depik Jurnal
Bireuen District has significant potential in fisheries resources. However, the high potential of marine fisheries comes with various threats, such as overfishing and destructive fishing, which can disrupt the sustainability of marine ecosystems. The use
Rizka Maula, Makwiyah A. Chaliluddin, Ichsan Setiawan, Indra Indra, Muhammad Rusdi   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source