Results 51 to 60 of about 25,873 (260)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
UPAYA KONSERVASI INDONESIA ATAS SUMBER DAYA IKAN DI LAUT LEPAS
Fiat Justisia, 2016 The principle of freedom of fishing on the high seas was recognized as one of the principles in customary international law, the Geneva Convention on the High Seas1958, and Part VII of UNCLOS 1982. Regarding to thehigh level of utilization of fish led to
Muhammad Insan Tarigan
doaj
Governance for responsible fisheries: an ecosystem approach.
, 2003 The term, ‘responsible’ can be interpreted in many ways. For fisheries, we believe responsible means sustainable production of human benefits, which are distributed ‘fairly’, without causing unacceptable changes in marine ecosystems. Governance is broader than fisheries management.
M. P. Sissenwine, P. M. Mace
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The role of human rights in implementing socially responsible seafood.
PLoS ONE, 2019 Sustainability standards for seafood mainly address environmental performance criteria and are less concerned with the welfare of fisheries workers who produce the seafood.
Lydia C L Teh +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Farming the Sea: The Only Way to Meet Humanity's Future Food Needs
GeoHealth, 2019 A major change began 10,000–12,000 years ago when humans began to practice agriculture. A series of “green revolutions” enabled the human population to explode, but these advancements have dramatically changed the planet. The United Nations predicts that
Jerry R. Schubel, Kimberly Thompson
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Peskas: Automated analytics for small-scale, data-deficient fisheries
SoftwareXSmall-scale fisheries account for almost 90 % of global fisheries employment and are responsible for landing >40 % of the world's fish catch. Yet their importance to livelihoods and food and nutrition security in Least Developed Countries are only ...
Lorenzo Longobardi +4 more
doaj +1 more source