Results 91 to 100 of about 1,402,994 (298)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Responsible innovation in public policy: Compulsory banking of the elderly in Argentina

Trilogía Ciencia Tecnología Sociedad, 2015
since March 2012, Argentine retirees and pensioners receive their salaries through a savings bank compulsorily, according to the provisions of a law passed in October 2011 (regulated by the Central Bank of Argentine
Adriana Fassio, Javier Ignacio García Fronti   +1 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Report on Responsible Research and Innovation (RRI) Workshop [PDF]

, 2015
The potential for an ongoing interdisciplinary conversation about RRI at the University of Nottingham (UoN) was identified during a research project conducted in summer 2014 to investigate how RRI is being interpreted within UoN (Pearce et al., 2014 ...
Hadley Kershaw, Eleanor, Hartley, Sarah, Pearce, Warren   +2 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Innovating innovation policy: the emergence of ‘Responsible Research and Innovation’ [PDF]

, 2015
Within the policy structures of the European Union (EU), the concept of ‘Responsible Research and Innovation’ (RRI) appears to have a very specific emergence point, via a workshop for invited experts hosted by the European Commission's Directorate ...
COM(2001) 428 final, COM(2005) 24 final, COM(2007) 161, COM(2010) 2020 final, COM(2010) 546 final, COM(2011) 48, COM(2011) 810 final, COM(95) 688, Huza Alexandru, Jasanoff Sheila, Schmitter Phillippe, Tallacchini Mariachiara   +11 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Wake up and Smell the Ginseng: International Trade and the Rise of Incremental Innovation in Low-Wage Countries [PDF]

Increasingly, a small number of lowwage countries such as China, India and Mexico are involved in incremental innovation. That is, they are responsible for resolving productionline bugs and suggesting product improvements. We provide evidence of this new
Daniel Trefler, Diego Puga
core  

The Limits of Responsible Innovation: Exploring Care, Vulnerability and Precision Medicine [PDF]

, 2018
Drawing on insights from feminist and Science and Technology Studies writing on care and vulnerability, this paper will critically explore conceptualisations of responsibility, care and vulnerability in relation to contemporary approaches to Responsible ...
Alyass, Anderson, Anne Kerr, Aronson, Bell, Bell, Boiten, Brown, Butler, Callon, Catapult Precision Medicine, Christopher Till, Cloud, Conti, Coyle, Dakin, Day, de la Bellacasa, De Saille, Di Guilio, Dijck, EPSRC, Fisher, Flores, Genomics England, Genomics England, NHS Genomic Medicine Centres, Groves, Groves, Hallowell, Hochschild, James, Johansson, Keating, Kirchgaessner, Knoppers, Kohane, Lupton, Mackenzie, Martin, Mol, Moye, National Cancer Institute, National Data Guardian, National Institutes of Health, NICE, Novas, Owen, Pullman, Rosemary L. Hill, Sinding, Sinding, Stilgoe, Stratified Medicine Scotland, Sulik, Tronto, Van Oudheusden, Viseu, Von Schomberg, Wahlster   +58 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source