Results 71 to 80 of about 1,402,994 (298)

Deliberating stratospheric aerosols for climate geoengineering and the SPICE project [PDF]

, 2013
Increasing concerns about the narrowing window for averting dangerous climate change have prompted calls for research into geoengineering, alongside dialogue with the public regarding this as a possible response.
A Corner, A Corner, A Irwin, A Rip, A Stirling, AP Nielsen, B Wynne, BA Turner, C Hamilton, C Marris, D Bhattachary, D Fiorino, DH Guston, HD Matthews, HJ Buck, J Brown, J Chilvers, J Chilvers, J Lezaun, JS Dryzek, K Bickerstaff, K Parkhill, M Callon, M Philbrick, MD Cobb, NE Vaughan, NF Pidgeon, NF Pidgeon, NF Pidgeon, NF Pidgeon, NF Pidgeon, O Renn, O Renn, P Harremoës, P Macnaghten, P Macnaghten, R Owen, RV Burri, S Jasanoff, S Rayner, SM Gardiner, T Dietz, T Rogers-Hayden   +42 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Patent Activity of Countries and Sectors in Graphene-Based Technologies

Studia i Materiały
Purpose: The aim of this article is to analyse the patent activity of various countries, regions, and sectors (academic, private, governmental) from 2000 to 2018, identifying global leaders in graphene-based technologies.
Piotr Nawrocki
doaj   +1 more source

Assessment of Responsible Innovation [PDF]

, 2020
Responsible Innovation encourages innovators to work together with stakeholders during the research and innovation process, to better align the outcomes of innovation with the values, needs and expectations of society. Assessing the benefits and costs of Responsible Innovation is crucial for furthering the responsible conduct of science, technology and
Yaghmaei, Emad, van de Poel, Ibo
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Responsible innovation [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2014
Stahl, BC, Jirotka, M, Eden, G, Timmermans, J, Hartswood, M   +4 more
openaire   +4 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Collingridge and the dilemma of control: towards responsible and accountable innovation [PDF]

, 2017
The paper critically reviews the work of David Collingridge in the light of contemporary concerns about responsibility and accountability in innovation, public engagement with science and technology, and the role of scientific expertise in technology ...
Andy Stirling, Arthur, Asante, Audley Genus, Beck, Beck, Bernal, Bernal, Blok, Blok, Chilvers, Collingridge, Collingridge, Collingridge, Collingridge, Collingridge, Collingridge, Collingridge, Conrad, De Bakker, Donnelley, Dryzek, Felt, Felt, Fonseca, Fonseca, GEA, Genus, Genus, Giddens, Grinbaum, Guston, Guston, Guston, Haldane, House of Lords, Irwin, Irwin, Jasanoff, Jasanoff, Johnston, Jonas, Kiran, Lee, Lindblom, Lindblom, Lövbrand, Macnaghten, Martin, Meadowcroft, Millstone, Nordmann, Owen, Owen, Owen, Pielke, Popper, Rip, Roco, Rose, Rose, Schot, Schot, Selin, Shove, Smith, Stahl, STEPS Centre, Stilgoe, Stilgoe, Stirling, Stirling, Stirling, Stirling, Stirling, Stirling, Sutcliffe, Sykes, Van de Poel, Van den Hoven, Van Oudheusden, Von Schomberg, Von Schomberg, Von Schomberg, Walport, Wickson, Winner, Wynne, Wynne, Wynne, Wynne, Ziman   +91 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Design-based methods for exploring ethical questions in the field of neurotechnologies

Journal of Responsible Innovation
Numerous complex and multi-faceted ethical questions arise from the innovation of neurotechnologies. Addressing these issues effectively requires the involvement of a diverse range of stakeholders, including patients, treatment providers, home users ...
Johannes Breuer, Moritz Julian Maier, Anne Bansen, Perianen Ramasawmy, Andrea Antal, Antonio Oliviero, Georg Northoff, Adrian Carter, Marie-Lena Heidingsfelder   +8 more
doaj   +1 more source