Results 81 to 90 of about 1,402,994 (298)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reclaiming ‘responsible research and Innovation’ as a generative concept: lessons from China

Journal of Responsible Innovation
This perspective commentary reflects on recent frustrations with the institutionalization of ‘Responsible Research and Innovation’ (RRI) in Europe and vibrant debates about the same notion in China.
David Ludwig
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Stakeholder perspectives on non-invasive brain stimulation

Scientific Reports
Non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS) have made great progress in recent years and offer boundless potential for the neuroscientific research and
Moritz Julian Maier, Perianen Ramasawmy, Johannes Breuer, Anne Bansen, Antonio Oliviero, Georg Northoff, Andrea Antal   +6 more
doaj   +1 more source

Small Responsible Innovators and Open Innovation towards Sustainability: Networks Conditions [PDF]

, 2013
Open innovation is key for innovators responding to major problems in the world, including energy, healthcare, water and the environment, and bringing transitions in socio-technical systems near. This paper has a focus on university spin-off companies as
Geenhuizen, Marina Van, Ye, Qing
core  

Responsible innovation [PDF]

Ekonomiczne Problemy Usług, 2016
Innovation is very important for the development of economies, competitiveness of companies and sustainable growth of countries and regions. However, sometimes it occurs irresponsible. Medicines cause people die, internet is a kind of threat for the data protection, some environmental innovation don’t protect the environment.
openaire   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Academic institutional entrepreneurs in Germany: navigating and shaping multi-level research commercialization governance

Triple Helix, 2018
Resumen Usando archivos institucionales y entrevistas con investigadores y administradores en el estado alemán de Renania del Norte-Westfalia, encontramos que los administradores deciden la profundidad de su relación con los investigadores basados en el ...
Liudvika Leišytė, Lisa Sigl
doaj   +1 more source

Inovação responsável através de fronteiras: tensões, paradoxos e possibilidades [PDF]

, 2015
In March 2014 a group of early career researchers and academics from São Paulo state and from the UK met at the University of Campinas to participate in a workshop on ‘Responsible Innovation and the Governance of Socially Controversial Technologies’.
Azevedo, Adalberto, Campo, André Luiz Sica de, Chilvers, Jason, Costa, Janaina Pamplona da, Dagnino, Renato, Frow, Emma, Garvey, Brian, Giulio, Gabriela Di, Groves, Christopher, Hartley, Sarah, Knobel, Marcelo, Kobayashi, Elizabete, Lehtonen, Markku, Macnaghten, Phil, Martin, Javier Lezaun James, Mello, Leonardo Freire de, Monteiro, Marko, Owen, Richard, Rigolin, Camila, Rondani, Bruno, Staykova, Margarita, Stilgoe, Jack, Taddei, Renzo, Till, Chris, Tyfield, David, Velho, Léa, Wilford, Sara, Wynne, Brian   +27 more
core   +3 more sources