Results 81 to 90 of about 3,537,691 (295)
Design-based methods for exploring ethical questions in the field of neurotechnologies
Journal of Responsible InnovationNumerous complex and multi-faceted ethical questions arise from the innovation of neurotechnologies. Addressing these issues effectively requires the involvement of a diverse range of stakeholders, including patients, treatment providers, home users ...
Johannes Breuer +8 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Reclaiming ‘responsible research and Innovation’ as a generative concept: lessons from China
Journal of Responsible InnovationThis perspective commentary reflects on recent frustrations with the institutionalization of ‘Responsible Research and Innovation’ (RRI) in Europe and vibrant debates about the same notion in China.
David Ludwig
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Stakeholder perspectives on non-invasive brain stimulation
Scientific ReportsNon-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS) have made great progress in recent years and offer boundless potential for the neuroscientific research and
Moritz Julian Maier +6 more
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Novation, 2020 This paper argues that responsible innovation discourses must consider the changing nature of digital innovation, if they are to stand a chance of steering the development of technology towards democratically-acceptable ends.
Vincent Bryce +3 more
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Ekonomiczne Problemy Usług, 2016 Innovation is very important for the development of economies, competitiveness of companies and sustainable growth of countries and regions. However, sometimes it occurs irresponsible. Medicines cause people die, internet is a kind of threat for the data protection, some environmental innovation don’t protect the environment.
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source