Results 61 to 70 of about 1,343,626 (305)

Responsible Research and Innovation: responding to the new research agenda [PDF]

, 2014
Responsible Research and Innovation (RRI) is concerned with the nature and trajectory of research and innovation: what it can do for society and who gets to decide. RRI has been embedded in key funding institutions such as EPSRC (Engineering and Physical
Hartley, Sarah, Pearce, Warren, Taylor, Alasdair   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Establishing circularity: development and validation of the circular work value scale (CWVS)

Frontiers in Psychology
ObjectivesAddressing the lack of German-language instruments, this study aims to develop a questionnaire that enables the measurement of work values. According to the theory of basic human values (Schwartz, 1992), a culturally fitting questionnaire is ...
Jannick Schneider, Jannick Schneider, Clemens Striebing, Katharina Hochfeld, Timo Lorenz   +4 more
doaj   +1 more source

Report on Responsible Research and Innovation (RRI) Workshop [PDF]

, 2015
The potential for an ongoing interdisciplinary conversation about RRI at the University of Nottingham (UoN) was identified during a research project conducted in summer 2014 to investigate how RRI is being interpreted within UoN (Pearce et al., 2014 ...
Hadley Kershaw, Eleanor, Hartley, Sarah, Pearce, Warren   +2 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Power, agency, deference and difference Examining the politics of composer–performer relationships in the wake of recent innovations [PDF]

, 2016
With a view to uncovering the political implications of notational, technological and musical innovation in composer–performer relationships within Western art music, this paper examines three disparate works: Christian Wolff’s Duo for Pianists II (1958);
Aulich, John
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Responsible research and innovation in the UK university: the politics of research governance [PDF]

, 2016
‘Responsible research and innovation’ (RRI) is a policy tool intended to shape scientific research as a means to achieve public value beyond economic growth. RRI calls for public involvement in the research process, and increased capacity for researchers
Hartley, Sarah, Pearce, Warren
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A New Bet for Scientists? Implementing the Responsible Research and Innovation (RRI) approach in the practices of research institutions

Relations, 2017
In last years, the European Commission has promoted an approach that seeks to anticipate and assess potential implications and societal expectations with regard to research and innovation, with the aim to foster the “design of inclusive and sustainable ...
Alba L’Astorina, Monica Di Fiore
doaj   +1 more source