Results 81 to 90 of about 1,354,140 (303)

Against the tide of depoliticisation: The politics of research governance [PDF]

, 2017
Research has identified a general trend towards depoliticisation. Against this trend, we identify opportunities for politicisation through the international emergence of a research governance tool: ‘responsible research and innovation’ (RRI).
Hartley, S., Pearce, W., Taylor, A.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Opening up Responsible Research and Innovation

Exchanges
Responsible research and innovation (RRI) is increasingly being implemented by researchers, and in the UK, its use is encouraged by funders such as UK Research and Innovation (UKRI). The aim of RRI is to ensure that research and its impacts are opened up
Catherine Price, Min Burdett, Tom Bott
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Implementing Responsible Research and Innovation

, 2021
This open access book offers a unique and practically oriented study of organisational and national conditions for implementing Responsible Research Innovation (RRI) policies and practices. It gives the reader a thorough understanding of the different aspects of RRI, and of barriers and drivers of implementation of RRI related policies.
Wittrock, Christian, Forsberg, E.M., Pols, A.J.K., Macnaghten, P.M., Ludwig, D.J.   +4 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

What drives change? Dynamic institutionalizations of responsible research and innovation in organizations: reflections on the role of institutional entrepreneurship

Journal of Responsible Innovation
While most innovations are developed in organizations, there is a wide-spread consensus that the organizational institutionalization of Responsible (Research and) Innovation is limited. This may partly be the case because we lack an understanding of what
Peter Biegelbauer, Martijn Wiarda, Petra Wagner, Caroline Lackinger, Mika Nieminen, Santtu Lehtinen, Emad Yaghmaei, Alice Ampolini   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Responsible Innovation (RI) in the midst of an innovation crisis [Full Thematic Issue]

Novation, 2020
The concept of Responsible Innovation (RI) occupies a central place in the discourse on science and technology, especially in the context of the European Union (EU) but also within academia.
Lucien von Schomberg, Vincent Blok
doaj   +1 more source

Small Responsible Innovators and Open Innovation towards Sustainability: Networks Conditions [PDF]

, 2013
Open innovation is key for innovators responding to major problems in the world, including energy, healthcare, water and the environment, and bringing transitions in socio-technical systems near. This paper has a focus on university spin-off companies as
Geenhuizen, Marina Van, Ye, Qing
core