Results 61 to 70 of about 1,354,140 (303)

Agriculture 4.0: broadening responsible innovation in an era of smart farming [PDF]

, 2018
Agriculture is undergoing a technology revolution supported by policy-makers around the world. While smart technologies will play an important role in achieving enhanced productivity and greater eco-efficiency, critics have suggested that a consideration
Asveld, Bear, Blok, Bronson, Burall, Carbonell, Carolan, Carson, Chilvers, Chilvers, Chilvers, Dicks, Dicks, Driessen, Eastwood, Fennimore, Firbank, Frankelius, Gadanakis, Goodman, Gunton, Gupta, Hajer, Hartley, Higgins, Holloway, Holloway, Jasanoff, Klerkx, Leach, Lejon, Long, Lottes, López, Macnaghten, Macnaghten, Macnaghten, Mahon, Marres, Nordmann, Pretty, Purwins, Rogers, Rose, Rose, Rose, Rose, Satterthwaite, Sen, Smith, Stilgoe, Struik, Tambo, Waters-Bayer, Whitfield, Wolf, Wolfert, Woolston   +57 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Establishing circularity: development and validation of the circular work value scale (CWVS)

Frontiers in Psychology
ObjectivesAddressing the lack of German-language instruments, this study aims to develop a questionnaire that enables the measurement of work values. According to the theory of basic human values (Schwartz, 1992), a culturally fitting questionnaire is ...
Jannick Schneider, Jannick Schneider, Clemens Striebing, Katharina Hochfeld, Timo Lorenz   +4 more
doaj   +1 more source

Beyond Research Ethics: Dialogues in Neuro-ICT Research [PDF]

, 2019
open access articleThe increasing use of information and communication technologies (ICTs) to help facilitate neuroscience adds a new level of complexity to the question of how ethical issues of such research can be identified and addressed.
Akintoye, Simisola, Fothergill, B. Tyr, Guerrero, Manuel, Knight, William, Stahl, Bernd Carsten, 1968-, Ulnicane, Inga   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Responsible research and innovation in science education: insights from evaluating the impact of using digital media and arts-based methods on RRI values [PDF]

, 2020
The European Commission policy approach of Responsible Research and Innovation (RRI) is gaining momentum in European research planning and development as a strategy to align scientific and technological progress with socially desirable and acceptable ...
Berrens Torruella, Karla, Heras López, Maria, Ruiz Mallen, Isabel   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The fragility of responsibility. norway’s transformative agenda for research, innovation and business, Edited by Giovanni De Grandis and Anne Blanchard, volume 9 of De Gruyter studies in innovation and entrepreneurship, an open access publication

Journal of Responsible Technology
This is a review of The Fragility of Responsibility. Norway’s Transformative Agenda for Research, Innovation and Business, Edited by Giovanni De Grandis and Anne Blanchard, which describes Norwegian approaches to addressing responsibility in innovation ...
Jonathan Hankins
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source