Results 61 to 70 of about 313,676 (255)

Innovating innovation policy: the emergence of ‘Responsible Research and Innovation’ [PDF]

Journal of Responsible Innovation, 2015
Within the policy structures of the European Union (EU), the concept of ‘Responsible Research and Innovation’ (RRI) appears to have a very specific emergence point, via a workshop for invited experts hosted by the European Commission's Directorate-General for Research and Innovation in May 2011.
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Toward institutionalization of responsible research and innovation: insights from case studies of technological centers in Spain

Journal of Responsible Innovation
The frameworks governing Responsible Research and Innovation (RRI) are heterogeneous and constantly evolving and adapting. We build upon this adaptability to explore the potential development of RRI in Research and Technology Organizations.
Hannia Gonzalez-Urango, Carmen Corona-Sobrino, Mónica García-Melón, Pedro Marques   +3 more
doaj   +1 more source

Reflections on the practice of Responsible (Research and) Innovation in synthetic biology

New Genetics and Society, 2020
This paper is a critical reflection on the concepts of Responsible Innovation (RI) and Responsible Research and Innovation (RRI). We offer an account of the emergence of these related but different accounts of responsible innovation that have recently ...
Ken Taylor, Simon Woods
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Opening up Responsible Research and Innovation

Exchanges
Responsible research and innovation (RRI) is increasingly being implemented by researchers, and in the UK, its use is encouraged by funders such as UK Research and Innovation (UKRI). The aim of RRI is to ensure that research and its impacts are opened up
Catherine Price, Min Burdett, Tom Bott
doaj   +1 more source

The roles of responsible innovation researchers in research projects

Journal of Responsible Innovation
The way in which responsible innovation (RI) is interpreted and implemented depends to a significant degree on how the researchers, scholars and practitioners who work on RI see their own work. There have been several contributions to the RI discourse suggesting distinctive roles that RI researchers may adopt. In this article we present the findings of
Bernd Carsten Stahl, Adebowale Owoseni, Carolyn Ten Holter   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Addressing responsible research and innovation to industry [PDF]

ACM SIGCAS Computers and Society, 2016
Responsible research and innovation (RRI) is taking a role to assist all types of stakeholders including industry to move research and innovation initiatives to responsible manner for tackling grand challenges. The literature on RRI focuses little on how industry can implement RRI principles.
openaire   +2 more sources