Results 91 to 100 of about 1,354,140 (303)

Properties of polypyrrole polyvinilsulfate films for dual actuator sensing systems [PDF]

open access: yes, 2017
One of the challenges of modern science is the development of actuators able to sense working conditions while actuation, mimicking the way in which biological organs work. Actuation of those organs includes nervous (electric) pulses dense reactive gels,
Fernández Otero, Toribio   +2 more
core   +2 more sources

Gender-Responsive Research and Innovation: Issues and Initiatives

open access: yesSustainability
The demands and preferences of men are often prioritized in societal challenges, despite women comprising half of the world’s population. Gender-Responsive Research and Innovation (GRRI) offers an approach to address this bias, promoting comprehensive and equitable solutions to better-understood real-world problems.
Sanaz Nikghadam-Hojjati   +13 more
openaire   +3 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Addressing directionality: Orientation failure and the systems of innovation heuristic. Towards reflexive governance

open access: yes, 2016
[Introduction] Since about 15 years, science, technology and innovation (STI) policies are increasingly geared towards addressing objectives reaching beyond an immediate economic focus on growth and competitiveness.
Beckert, Bernd   +7 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Could rri approach play key role in establishment of circular economy? [PDF]

open access: yes, 2007
The paper considers a new model of economics - the model of circular economy (CE) that integratesenvironmental protection and economic efficiency in order to reach goals of sustainable development.The model of circular economy suggests to create virtuous
Ermushko, Zhanna Alexandrovna   +1 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Design-based methods for exploring ethical questions in the field of neurotechnologies

open access: yesJournal of Responsible Innovation
Numerous complex and multi-faceted ethical questions arise from the innovation of neurotechnologies. Addressing these issues effectively requires the involvement of a diverse range of stakeholders, including patients, treatment providers, home users ...
Johannes Breuer   +8 more
doaj   +1 more source

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