Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
The Undergraduate as an Engaged Explorer [PDF]
This paper asserts that most undergraduates leave Irish universities short-changed, never having been exposed to the riches of research.
Finbarr Bradley, Gerry Boyle
core
Analysis of building energy upgrade technologies for implementing the dual energy efficiency and demand response scheme for non-residential buildings [PDF]
, 2019 The continuous growth of renewable energy and the transition to a more de-centralised electricity generation adds significant complexity to balance power supply and demand in the grid.
Bucur, Mircea +7 more
core +2 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Stakeholder perspectives on non-invasive brain stimulation
Scientific ReportsNon-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) or transcranial magnetic stimulation (TMS) have made great progress in recent years and offer boundless potential for the neuroscientific research and
Moritz Julian Maier +6 more
doaj +1 more source
What on Earth is Responsible Innovation anyway? (And how to make it happen) [PDF]
, 2016 The case for Responsible Innovation has been well articulated in the areas of science research and Corporate Social Responsibility in business. This paper presents a case for adopting a design-led approach in order to promote responsibility in innovation.
Bailey, Mark +4 more
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Responsible Data Governance of Neuroscience Big Data [PDF]
, 2019 Open access article.Current discussions of the ethical aspects of big data are shaped by concerns regarding the social consequences of both the widespread adoption of machine learning and the ways in which biases in data can be replicated and perpetuated.
Fothergill, B. Tyr +3 more
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Journal of Responsible InnovationRe-founding RRI in a cosmopolitan world is a philosophical project aimed at global justice. Originating in Europe, RRI's introduction outside Europe sits in tension with nationalism.
Han Zhang, Jie Gao, Feng Zhang
doaj +1 more source
Power, agency, deference and difference Examining the politics of composer–performer relationships in the wake of recent innovations [PDF]
, 2016 With a view to uncovering the political implications of notational, technological and musical innovation in composer–performer relationships within Western art music, this paper examines three disparate works: Christian Wolff’s Duo for Pianists II (1958);
Aulich, John
core +1 more source