Results 51 to 60 of about 60,482 (258)

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Clinical applications of resting state functional connectivity

Frontiers in Systems Neuroscience, 2010
During resting conditions the brain remains functionally and metabolically active. One manifestation of this activity that has become an important research tool is spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of fMRI.
Michael D Fox, Michael Greicius
doaj   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

Examining resting-state functional connectivity in first-episode schizophrenia with 7T fMRI and MEG

NeuroImage: Clinical, 2019
Schizophrenia is often characterized by dysconnections in the brain, which can be estimated via functional connectivity analyses. Commonly measured using resting-state functional magnetic resonance imaging (fMRI) in order to characterize the intrinsic or
Kristin K. Lottman, Timothy J. Gawne, Nina V. Kraguljac, Jeffrey F. Killen, Meredith A. Reid, Adrienne C. Lahti   +5 more
doaj   +1 more source

Loss of resting-state posterior cingulate flexibility is associated with memory disturbance in left temporal lobe epilepsy. [PDF]

PLoS ONE, 2015
The association between cognition and resting-state fMRI (rs-fMRI) has been the focus of many recent studies, most of which use stationary connectivity.
Linda Douw, Catherine L Leveroni, Naoaki Tanaka, Britt C Emerton, Andrew J Cole, Claus Reinsberger, Steven M Stufflebeam   +6 more
doaj   +1 more source

An implementation of integrated information theory in resting-state fMRI

Communications Biology, 2023
AbstractIntegrated Information Theory was developed to explain and quantify consciousness, arguing that conscious systems consist of elements that are integrated through their causal properties. This study presents an implementation of Integrated Information Theory 3.0, the latest version of this framework, to functional MRI data.
Idan Efim Nemirovsky, Nicholas J. M. Popiel, Jorge Rudas, Matthew Caius, Lorina Naçi, Nicholas D. Schiff, Adrian M. Owen, Andrea Soddu   +7 more
openaire   +4 more sources

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

A study of neural activity and functional connectivity within the olfactory brain network in Parkinson's disease

NeuroImage: Clinical, 2019
Olfactory dysfunction is an early manifestation of Parkinson's disease (PD). The present study aimed to illustrate potential differences between PD patients and healthy controls in terms of neural activity and functional connectivity within the olfactory
Charalampos Georgiopoulos, Suzanne T. Witt, Sven Haller, Nil Dizdar, Helene Zachrisson, Maria Engström, Elna-Marie Larsson   +6 more
doaj   +1 more source

Resting-State Functional Connectivity in Mathematical Expertise

Brain Sciences, 2021
To what extent are different levels of expertise reflected in the functional connectivity of the brain? We addressed this question by using resting-state functional magnetic resonance imaging (fMRI) in mathematicians versus non-mathematicians.
Miseon Shim, Han-Jeong Hwang, Ulrike Kuhl, Hyeon-Ae Jeon   +3 more
doaj   +1 more source