Results 91 to 100 of about 285,581 (295)
Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
Advanced Science, EarlyView.A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun +9 more
wiley +1 more source
Distribution of microreticulate dinoflagellate cysts from the Galician and Portuguese coast
Scientia Marina, 1999 In May 1993, surface sediment samples from the west coast of the Iberian Peninsula were collected with the aim of studying the geographic distribution of G. catenatum resting cysts. The sampling area ranged from 40º 39´ N (Portugal) to 42º 38´ N (Galicia,
I. Bravo, I. Ramilo
doaj +1 more source
Advanced Science, EarlyView.High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling +18 more
wiley +1 more source
Biotechnology & Biotechnological Equipment, 2018 Resting stages are common for the life cycle of some phytoplankton species, including blooming and potentially toxic species. The “seed bank” accumulated in the sediments can initiate blooms in the water column and could be an early warning signal of ...
Nina Dzhembekova +4 more
doaj +1 more source
Spatial And Temporal Variability Of Dinoflagellate Cyst Abundance In A Tidal Estuary
, 1983 A study of dinoflagellate cysts was made in an estuary near Plymouth, England for 1 yr. The data show that the cysts were most concentrated in sediments near the entrance of the estuary (3000 cysts (mL∙flocculant−1)) and less concentrated upstream (<
Surreygent, SC +5 more
core +1 more source
The feeding tube of cyst nematodes:characterisation of protein exclusion [PDF]
, 2014 Plant parasitic nematodes comprise several groups; the most economically damaging of these are the sedentary endoparasites. Sedentary endoparasitic nematodes are obligate biotrophs and modify host root tissue, using a suite of effector proteins, to ...
Jones, John T. +30 more
core +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
The role of osteoblast cells in the pathogenesis of unicameral bone cysts
, 2012 PurposeThe pathogenesis of unicameral bone cysts (UBCs) remains largely unknown. Osteoclasts have been implicated, but the role of osteoblastic cells has, to date, not been explored.
Tayton, Edward R +13 more
core +1 more source