Results 61 to 70 of about 267,373 (297)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Relation between Healthy Eating Index and Resting Metabolic Rate

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Previouse studies demonstrated inverse association between healthy eating index and alot of chronic diseases like cardiovascular disease and cancer and mortality.
Mojdeh Ebaditabar, Samira Davarzani, Nadia Babaei, sakineh Shabbidar   +3 more
doaj  

Accelerometer Derived Activity Counts and Oxygen Consumption between Young and Older Individuals

Journal of Aging Research, 2014
The purpose of this investigation was to compare accelerometer activity counts and oxygen consumption between young and elderly individuals. Sixteen young (21.3±2.5 yrs) and sixteen elderly (66.6±2.9 yrs) participants completed 30 minutes of resting ...
Lucas Whitcher, Charilaos Papadopoulos
doaj   +1 more source

Winter Is Coming: Seasonal Variation in Resting Metabolic Rate of the European Badger (Meles meles). [PDF]

PLoS ONE, 2015
Resting metabolic rate (RMR) is a measure of the minimum energy requirements of an animal at rest, and can give an indication of the costs of somatic maintenance.
David W McClune, Berit Kostka, Richard J Delahay, W Ian Montgomery, Nikki J Marks, David M Scantlebury   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets

Nutrition & Metabolism, 2021
Background The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes.
Catia Martins, Jessica Roekenes, Barbara A. Gower, Gary R. Hunter   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparison of predictive equations for resting metabolic rate in Portuguese women

Motricidade, 2020
Obesity represents a public health challenge and dietary interventions to prevent or treat obesity rely on the ability to accurately determine daily energy requirements - which are based on measures of total energy expenditure.
José Maria Tallon, Janine Narciso, Raquel Saavedra, António José Silva, Ana Barros, Aldo Matos da Costa   +5 more
doaj   +1 more source

Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats. [PDF]

, 2014
BACKGROUND: We considered of interest to evaluate how aging affects mitochondrial function in skeletal muscle. METHODS: We measured mitochondrial oxidative capacity and proton leak, together with lipid oxidative damage, superoxide dismutase specific ...
Bianco F, CRESCENZO, RAFFAELLA, Giacco A, IOSSA, SUSANNA, LIVERINI, GIOVANNA, MAZZOLI, ARIANNA   +5 more
core   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source