Results 111 to 120 of about 73,120 (346)

Compound Heterozygous Structural Variants in Cases with Unsolved PRKN‐Associated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Biallelic mutations in the PRKN gene are a common cause of early‐onset Parkinson's disease (EOPD). In addition to single nucleotide variants, structural variants contribute substantially to the mutational profile of PRKN. A significant portion of patients with EOPD remains genetically unsolved.
Agata Fant, Sara Trova, Edoardo Monfrini, Gaia Treves, Francesco Musacchia, Fabio Landuzzi, Paola Mandich, Antonio Amoroso, Remo Sanges, Luca Pandolfini, Francesco Cavallieri, Franco Valzania, Valentina Fioravanti, Giulia Di Rauso, Gloria Brescia, Enza Maria Valente, Valeria Tiranti, Luigi Michele Romito, Chiara Reale, Barbara Garavaglia, Antonio Emanuele Elia, Andrea Cavalli, Alessio Di Fonzo, Manuela Vecchi, Stefano Gustincich   +24 more
wiley   +1 more source

Risk factors of primary and secondary restless legs syndrome among a middle-aged population in Saudi Arabia: A community-based study

Annals of Thoracic Medicine, 2018
INTRODUCTION: Restless legs syndrome (RLS) is etiologically divided into primary and secondary syndromes. However, a comparative description of both types is lacking in the literature.
Samah Alsafadi, Bahaa Abaalkhail, Siraj Omar Wali, Khaled Aljammali, Bedor Alotaiby, Ibrahim Zakaria, Hanadi Sabbahi   +6 more
doaj   +1 more source

Prevalence and determinants of periodic limb movements in the general population. [PDF]

, 2016
OBJECTIVE: Periodic limb movements during sleep (PLMS) are sleep phenomena characterized by periodic episodes of repetitive stereotyped limb movements.
Andries, D., Haba-Rubio, J., Heinzer, R., Kutalik, Z., Marques-Vidal, P., Marti-Soler, H., Preisig, M., Tafti, M., Tobback, N., Vollenweider, P., Waeber, G.   +10 more
core   +1 more source

A Biomarker‐Based Classification of Corticobasal Syndrome

Movement Disorders, EarlyView.
Abstract Background Corticobasal syndrome (CBS) is a clinically defined syndrome with progressive movement and cortical dysfunction, caused by various underlying pathologies, most commonly tau‐predominant pathologies such as progressive supranuclear palsy and corticobasal degeneration, or Alzheimer's disease (AD).
Carla Palleis, Alexander Maximilian Bernhardt, Endy Weidinger, Urban M. Fietzek, Alexander Jäck, Sabrina Katzdobler, Johannes Gnörich, Theresa Bauer, Nicolai Franzmeier, Robert Perneczky, German Imaging Initiative for Tauopathies (GII4T), Matthias Brendel, Johannes Levin, Günter U. Höglinger   +13 more
wiley   +1 more source

Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism

Sleep Science, 2014
Restless legs syndrome (RLS) is characterized by unpleasant sensations mainly in the legs. 43% of RLS-associated conditions have also been associated with systemic iron deficiency.
Paulo Daubian-Nosé, Miriam K. Frank, Andrea Maculano Esteves   +2 more
doaj   +1 more source

Saint John's wort, an herbal inducer of the cytochrome P4503A4 isoform, may alleviate symptoms of Willis-Ekbom's disease [PDF]

, 2013
OBJECTIVE: Certain drug classes alleviate the symptoms of Willis-Ekbom's disease, whereas others aggravate them. The pharmacological profiles of these drugs suggest that drugs that alleviate Willis-Ekbom's disease inhibit thyroid hormone activity ...
Alves, Rosana Cardoso, Pereira Junior, José Carlos, Pradella-Hallinan, Márcia Lurdes de Cássia   +2 more
core   +5 more sources

Switching Gears: From Intrajejunal Levodopa to Subcutaneous Foslevodopa

Movement Disorders Clinical Practice, EarlyView.
Walaa B. Mohammed, Alexandra McGuckin, Yu‐Yan Poon, Alfonso Fasano   +3 more
wiley   +1 more source

A geriatrician's approach to managing the complex older adult with obesity

Obesity, EarlyView.
Abstract The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight‐loss attempts during the middle years of life ...
Shenbagam Dewar
wiley   +1 more source

a previously undescribed entity [PDF]

, 2015
Background: There are few studies describing periodic limb movement syndrome (PLMS) in rapid eye movement (REM) sleep in patients with narcolepsy, restless legs syndrome, REM sleep behavior disorder, and spinal cord injury, and to a lesser extent, in ...
Gaede, Gunnar, Paul, Friedemann, Radbruch, Helena, Sieb, Joern-Peter, Veauthier, Christian, Wernecke, Klaus-Dieter   +5 more
core   +1 more source

The Management of Restless Legs Syndrome: An Updated Algorithm.

Mayo Clinic proceedings, 2021
M. Silber, M. Buchfuhrer, C. Earley, Brian B Koo, M. Manconi, J. Winkelman, Phillip Becker, J. Berkowski, S. Clemens, J. Connor, S. Ferré, Jennifer G. Hensley, Byron C. Jones, E. Karroum, Brian B Koo, W. Ondo, Kathy C. Richards, D. Sharon, M. Silber, L. Trotti, George Uhl, A. Walters, J. Winkelman   +22 more
semanticscholar   +1 more source